Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism [PDF]
Frontiers in Endocrinology, 2023 Distinguishing between self limited delayed puberty (SLDP) and congenital hypogonadotropic hypogonadism (CHH) may be tricky as they share clinical and biochemical characteristics. and appear to lie within the same clinical spectrum.
Valeria Vezzoli +11 more
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Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism [PDF]
Frontiers in Endocrinology, 2023 IntroductionDelayed puberty (DP) is a frequent concern for adolescents. The most common underlying aetiology is self-limited DP (SLDP). However, this can be difficult to differentiate from the more severe condition congenital hypogonadotrophic ...
Yuri Aung +24 more
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Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty [PDF]
npj Genomic Medicine, 2021 Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty.
Tansit Saengkaew +9 more
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Testosterone therapy in boys with constitutional delay of growth and puberty: a PubMed-based systematic review and exploratory meta-analysis [PDF]
Clinical and Experimental PediatricsConstitutional delay of growth and puberty (CDGP), the most common cause of delayed puberty in boys, accounts for the majority of pediatric endocrinology referrals.
Ashraf T. Soliman +7 more
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The Genetic Basis of Delayed Puberty
Frontiers in Endocrinology, 2019 Delayed pubertal onset has many etiologies, but on average two-thirds of patients presenting with late puberty have self-limited (or constitutional) delayed puberty. Self-limited delayed puberty often has a strong familial basis.
Sasha R. Howard
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EMBO Molecular Medicine, 2016 Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse health and psychosocial outcomes. Self‐limited delayed puberty (DP) segregates predominantly in an autosomal dominant pattern, but the underlying genetic ...
Sasha R Howard +19 more
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Clinical approach to the male with delayed puberty [PDF]
Archives of Endocrinology and MetabolismDisorders of pubertal onset and progression are a common cause for referral to paediatric endocrinologists, with delayed puberty in males being particularly frequent. Pubertal development depends on the hypothalamic-pituitary-testicular (HPT) axis, which
Rodolfo A. Rey +2 more
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Approaches to Identify Factors Associated With Pubertal Timing in Self-Limited Delayed Puberty [PDF]
Hormone Research in Paediatrics, 2023 Henry A Feldman, Enju Liu, Jia Zhu
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Adult Consequences of Self-Limited Delayed Puberty [PDF]
Pediatrics, 2017 Jia Zhu, Yee-Ming Chan
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Deleterious Variants in Intolerant Genes Reveal New Candidates for Self-Limited Delayed Puberty [PDF]
European Journal of EndocrinologyAna Claudia Latronico Xavier +2 more
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