Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Self-medication with Antimicrobial Drugs in Europe
Emerging Infectious Diseases, 2006 We surveyed the populations of 19 European countries to compare the prevalence of antimicrobial drug self-medication in the previous 12 months and intended self-medication and storage and to identify the associated demographic characteristics. By using a
Larissa Grigoryan +20 more
doaj +1 more source
Self-medication with sucrose [PDF]
Current Opinion in Behavioral Sciences, 2016 For many individuals, stress promotes the consumption of sweet, high-sugar foods relative to healthier alternatives. Daily life stressors stimulate the overeating of highly-palatable foods through multiple mechanisms, including altered glucocorticoid, relaxin-3, ghrelin and serotonin signaling in brain.
openaire +2 more sources
Pengaruh Penyuluhan Obat Menggunakan Leaflet terhadap Perilaku Pengobatan Sendiri di Tiga Kelurahan Kota Bogor [PDF]
, 2006 Research conducted to get information about the effectiveness of medication information among groups communications method by health center officer with interpersonal communications method by cadre use leaflet guidance of self-mediation to the properly ...
Notosiswoyo, M. (Mulyono) +1 more
core
Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia. [PDF]
, 2005 In the Maheba Refugee Settlement, in the clinics supported by Medecins Sans Frontieres, all children aged up to 5 years with a confirmed diagnosis of uncomplicated falciparum malaria are treated with the combination of sulfadoxine/pyrimethamine (SP) and ...
Bloland PB +9 more
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Other Side of Medicalization: Self-Medicalization and Self-Medication [PDF]
Culture, Medicine, and Psychiatry, 2013 The concept of medicalization has given rise to considerable discussion in the social sciences, focusing especially on the extension of medicine's jurisdiction and its hold over our bodies through the reduction of social phenomena to individual biological pathologies.
openaire +3 more sources
Pola Penggunaan Obat Dan Obat Tradisional Dalam Upaya Pengobatan Sendiri Di Tanjung Bintang, Lampung [PDF]
, 1997 Self-medication appeared to be the initial effort of around 60% of the urban community in three cities on Java Island, in 1993. Drugs were used more frequently than the traditional medicines.
Aziz, S. (Sriana) +2 more
core
Metarhizium anisopliae infection alters feeding and trophallactic behavior in the ant Solenopsis invicta [PDF]
, 2016 In social insects, social behavior may be changed in a way that preventing the spread of pathogens. We infected workers of the ant Solenopsis invicta with an entomopathogenic fungus Metarhizium anisopliae and then videotaped and/or measured worker ...
He, Yu-Rong +3 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source