Results 21 to 30 of about 466 (152)

Atypical parkinsonism and self‐mutilation: A new lens on the old concept

Clinical Case Reports, 2021
We report a case of atypical parkinsonism and self‐mutilation.
Mehri Salari, Masoud Etemadifar, Kimia Ghanbari   +2 more
doaj   +1 more source

Case of Self-Mutilation –Lesch-Nyhan Syndrome

Journal of College of Medical Sciences-Nepal, 2022
Lesch-Nyhan syndrome involves a congenital error of purine metabolism, due to the absence (or very low levels) of hypoxanthine-guanine phosphoribosyltransferase (HPRT) enzyme. The classic clinical phenotype of LNS was first described by Michael Lesch and
Sweta Kumari Gupta, Samanata Dallakoti, Ranjit Sapkota, Niraj Sangroula   +3 more
doaj   +1 more source

Self-mutilation in neurodegeneration with brain iron accumulation

Indian Journal of Dermatology, 2015
Neurodegeneration with brain iron accumulation (NBIA) is the term applied to a heterogeneous group of disorders resulting in iron deposition in the basal ganglia.
Sadanandavalli Retnaswami Chandra, Pawan Raj, Thomas Gregor Issac   +2 more
doaj   +1 more source

Genital self mutilation in alcohol withdrawal state complicated with delirium

Indian Journal of Psychological Medicine, 2011
Genital self mutilation is a rare and a severe form of self-injurious behavior usually described in psychotic disorders, with delusions and hallucinations.
Sri Hari Charan, C. M. Pavan Kumar Reddy
doaj   +1 more source

Polydipsia/polyuria syndrome in a Congo African grey parrot (Psittacus erithacus erithacus):a case report [PDF]

The Iranian Journal of Veterinary Science and Technology, 2012
Polydipsia/polyuria syndrome is not a common manifestation in birds. Hyperglycemia was found on plasma chemistry in an African Grey Parrot (Psittacus erithacus), which was presented with polyphagia and self mutilation symptoms.
Jamshid Razmyar, Mohammad Heidarpour, Masoud Rajabioun   +2 more
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

PEG-Fusion Repair After Peripheral Nerve Injuries Enhances Behavioral Recovery and Reduces Self-Mutilation in Rat Models

Neurology International
Background/Objectives: Self-mutilation behavior is often triggered by neuropathic pain associated with peripheral nerve injuries (PNIs). Polyethylene glycol (PEG)-fusion is a repair method that rapidly joins/fuses the open ends of closely apposed severed
Liwen Zhou, Cathy Z. Yang, George D. Bittner   +2 more
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Anaesthetic Bodies and the Absence of Feeling: Pain and Self-Mutilation in Later Nineteenth-Century Psychiatry

19, 2012
This paper addresses the overlapping ways in which self-inflicted injury was understood in relation to an absence of pain during the long nineteenth century, arguing that a clear distinction between bodily and mental suffering cannot be made in this ...
Sarah Chaney
doaj   +2 more sources