Results 61 to 70 of about 4,485,837 (294)

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Self-beliefs and bullying : unravelling the relation between bullying, being bullied and self-concept for upper elementary school aged children

, 2006
Previous examinations of relations between bullying, victimisation, and self-concept have been flawed by erroneous research practices such as the un-attenuated use of dichotomous variables to measure relationships between continuous variables (Finger ...
Finger, Linda R., Dowson, Martin, Craven, Rhonda   +2 more
core  

Facilitators’ champion behaviors for delivering an evidence‐based parenting program

American Journal of Community Psychology, EarlyView.
Abstract Effective implementation of parenting programs relies on multiple factors, particularly the role of facilitators who actively deliver and support the intervention. Facilitators’ champion behaviors or the efforts they make to encourage implementation, can positively impact the outcomes of these programs.
Camila Regina Lotto, Elisa Rachel Pisani Altafim, Dana Charles McCoy, Maria Beatriz Martins Linhares   +3 more
wiley   +1 more source

The relation of self-concept to desirable educational outcomes

, 2006
Reviewers (Byrne, 1996a, 1996b; Hattie, 1992; Marsh, Byrne, & Shavelson, 1988; Marsh & Craven, 1997; Craven, Marsh, & Burnett, 2003) consider that self-concept is multifaceted and espouse that self-concept cannot be adequately understood if its ...
Craven, Rhonda, Munns, Geoff, Ha, My Trinh, Martin, Andrew J.   +3 more
core  

Becoming resilient: Community‐driven change and the Civic Capacity Index

American Journal of Community Psychology, EarlyView.
Abstract One of the principal features of successful community governance is that it is collaborative and thus dependent on a community's ability to work together. However, there are no valid, comprehensive means to assess a community's capacity to respond to civic challenges in collaborative ways, and that are predictive of community resilience and ...
David MacPhee, David Chrislip, Patti Schmitt   +2 more
wiley   +1 more source

A comprehensive multilevel model meta-analysis of self-concept interventions

, 2006
The efficacy of self-concept interventions has previously been examined through traditional meta-analytic methods, and a host of moderators of intervention outcomes have been identified (O’Mara, Marsh, & Craven, 2004; Haney & Durlak, 1998; Hattie, 1992).
Craven, Rhonda, Marsh, Herbert W., O'Mara, Alison J.   +2 more
core  

Transitioning to nonpunitive school policies for addressing student substance use: Qualitative interviews with key school administrators

American Journal of Community Psychology, EarlyView.
Abstract Recent policy change in Massachusetts encourages schools to limit their use of exclusionary discipline to “extraordinary circumstances,” but little work has explored the opportunities and challenges of transitioning to nonpunitive practices after student substance use infractions in schools.
Kristina Conroy, M. Grace Albright, Kendall B. Roberts, Meghan A. Costello, Anthony J. Jannetti, Alexis R. Wing, Randi M. Schuster   +6 more
wiley   +1 more source