Results 171 to 180 of about 17,810 (215)

Phenotypic Subtypes of Obstructive Eustachian Tube Dysfunction as Defined by Cluster Analysis

open access: yesThe Laryngoscope, EarlyView.
Obstructive ETD encompasses five clinically distinct phenotypes, ranging from mild, post‐upper respiratory infection presentations to chronic, bilateral disease driven by sinusitis and reflux. These were identified through hierarchical cluster analysis of 490 patients using seven key clinical variables.
Jenilkumar H. Patel   +4 more
wiley   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

open access: yesMed Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo   +8 more
wiley   +1 more source

Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1

open access: yesMovement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 1 (SCA1) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive cerebellar and brainstem degeneration. Previous studies have shown that spinal cord atrophy is also a key aspect of SCA1 neuropathology.
Colette J.M. Reniers   +11 more
wiley   +1 more source

Temporal Interference Stimulation Modulates Resting State Functional Connectivity of Motor Circuit in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Transcranial temporal interference stimulation (TIs) targeting the subthalamic nucleus (STN) is a novel noninvasive neuromodulation approach with potential to improve motor symptoms in Parkinson's disease (PD). However, its underlying neuroimaging mechanisms remain unclear.
Yongxin Xu   +19 more
wiley   +1 more source

Respiration Can Trigger Cerebrovascular Reactivity: A Novel Method to Quantify Cerebrovascular Resistance Dynamics Using Real‐Time Phase‐Contrast MRI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To directly quantify respiration‐driven cerebrovascular resistance dynamics (CRD) using a gas‐free MRI framework based on the internal‐to‐external artery carotid flow ratio (ratio_Q). Theory and Methods Two independent datasets (n = 10 and n = 17) were used to evaluate repeatability and to compare breathing conditions.
Pan Liu   +5 more
wiley   +1 more source

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