Normalisation of AHI Under Positive Pressure Therapy Does Not Necessarily Mean Control of Symptoms: A Comparison of the Effectiveness of APAP and CPAP on Daytime Sleepiness and Nocturnal Urination. [PDF]
Bivolaru S, Constantin A.
europepmc +1 more source
Phenotypic Subtypes of Obstructive Eustachian Tube Dysfunction as Defined by Cluster Analysis
Obstructive ETD encompasses five clinically distinct phenotypes, ranging from mild, post‐upper respiratory infection presentations to chronic, bilateral disease driven by sinusitis and reflux. These were identified through hierarchical cluster analysis of 490 patients using seven key clinical variables.
Jenilkumar H. Patel +4 more
wiley +1 more source
Mitigating Disparities in Prostate Cancer Survival Prediction Through Fairness-Aware Machine Learning Models. [PDF]
Do H, Ranganath R, Murray K, Nayan M.
europepmc +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Bridging the digital health divide: digital endowment, informal social participation, and health inequality among older adults. [PDF]
Cui Y, Bao H, Wen K, Wen H.
europepmc +1 more source
Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1
Abstract Background Spinocerebellar ataxia type 1 (SCA1) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive cerebellar and brainstem degeneration. Previous studies have shown that spinal cord atrophy is also a key aspect of SCA1 neuropathology.
Colette J.M. Reniers +11 more
wiley +1 more source
Revisiting big data optimism: risks of data-driven black box algorithms for society. [PDF]
Mahajan S, Helbing D.
europepmc +1 more source
Abstract Background Transcranial temporal interference stimulation (TIs) targeting the subthalamic nucleus (STN) is a novel noninvasive neuromodulation approach with potential to improve motor symptoms in Parkinson's disease (PD). However, its underlying neuroimaging mechanisms remain unclear.
Yongxin Xu +19 more
wiley +1 more source
SCMO: a deep learning model integrating the single-cell resolution TME ecosystem and multi-omics for survival prediction in CRC patients. [PDF]
He Z +10 more
europepmc +1 more source
ABSTRACT Purpose To directly quantify respiration‐driven cerebrovascular resistance dynamics (CRD) using a gas‐free MRI framework based on the internal‐to‐external artery carotid flow ratio (ratio_Q). Theory and Methods Two independent datasets (n = 10 and n = 17) were used to evaluate repeatability and to compare breathing conditions.
Pan Liu +5 more
wiley +1 more source

