Results 41 to 50 of about 6,892 (256)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 2011 We study a class of Markovian systems of N elements taking values in [0,1] that evolve in discrete time t via randomized replacement rules based on the ranks of the elements.
Grinfeld, Michael +7 more
core +1 more source
Self-organized criticality in neural networks
CoRR, 2021 We demonstrate, both analytically and numerically, that learning dynamics of neural networks is generically attracted towards a self-organized critical state. The effect can be modeled with quartic interactions between non-trainable variables (e.g. states of neurons) and trainable variables (e.g. weight matrix).
Mikhail I. Katsnelson +2 more
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Self-organized criticality in superferromagnets
, 2010 Kondratyev VN, Blanchard P. Self-organized criticality in superferromagnets. In: Strongly Correlated Electron Systems. Journal of Physics: Conference Series. Vol 200.
Kondratyev, V. N. +3 more
core +1 more source
Self organized criticality [PDF]
, 1993 Self organized criticality refers to the tendency of highly dissipative systems to drive themselves to a critical state. This has been proposed to explain why observed physics often displays a wide disparity of length and time scales.
Creutz, M.
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Self-Organized Criticality in Nanotribology
, 2003 We present experimental results on dry friction, which are consistent with the hypothesis that the stick-slip mechanism for energy release is described by self-organized criticality.
Micha Adler +4 more
core +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source