Results 71 to 80 of about 25,182 (261)
Pattern classification of human body's acupoints based on functional similarity in Traditional Chinese Medicine [PDF]
Network Biology, 2023 Based on previously constructed data tables of acupoint functions and meridians, we performed a pattern classification of acupoints based on functional similarity in this study.
WenJun Zhang, GuangHua Liu
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Self-organizing Maps and Ancient Documents [PDF]
, 2004 This paper presents how Self-Organizing Maps and especially Kohonen maps can be applied to digital images of ancient collections in the perspective of valorization and diffusion. As an illustration, a scheme of transparency reduction of the digitized Gutenberg Bible is presented. In this two steps method, the Kohonen map is trained to generate a set of
Smigiel, Eddie +2 more
openaire +2 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Human Face Recognition Using GABOR Filter And Different Self Organizing Maps Neural Networks
Al-Khawarizmi Engineering Journal, 2005 This work implements the face recognition system based on two stages, the first stage is feature extraction stage and the second stage is the classification stage.
Dr. Tarik Zeyad
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Determinants of Patent Protection Regimes: A Self-Organizing Map Approach
Review of Economic Perspectives, 2018 This study investigates the determinants of patent protection regimes with the use of the self-organizing map (SOM) method. Unlike any previous attempts in the existing literature, this paper takes into consideration the lack of analytical techniques in ...
Demir Caner, Cergibozan Raif
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source