Results 71 to 80 of about 6,509,197 (268)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Quality of life among older people with poor functioning. The influence of perceived control over life [PDF]

, 2007
Objective: to investigate the apparently incongruous coupling of poor physical functioning with high QoL.Study design and setting: face-to-face interview survey of random sample of 999 people aged 65+ across Britain.Results: twenty-one per cent of ...
Morris, R, Seetai, S, Morris, Richard, Seetai, Sharon, Ebrahim, Shah, Bowling, Ann, Ebrahim, S, Bowling, A   +7 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Social Networks of Self-care and Perceived Treatment Burden Among Patients on In-Center Hemodialysis

Kidney Medicine, 2019
Background: Dialysis patients manage not only the demand of dialysis but also other complex chronic conditions. These individuals may draw upon personal and social resources to cope with the demands of self-management and care coordination.
Mi-Kyung Song, Sudeshna Paul, Laura Plantinga, Carrie Henry, Linda Turberville-Trujillo   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Untangling the web : reports of self-concept, academic motivation and perceived discrimination for indigenous secondary students

, 2006
Recently, a new direction has emerged within the field of educational psychology that has sought to address the inequities between Indigenous Australian students and the wider Australian student population.
Craven, Rhonda, Bodkin-Andrews, Gawaian
core  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Self-esteem as an adaptive resource during a transitional event

, 2004
Self-esteem is a critical component of success in any high performance environment. A high level of self esteem is not only a consequence of success at an elite level, it also plays an important role as a buffer against negative events which may occur as
Tremayne, Patsy, Marsh, Herbert W., Burden, Sharon A.   +2 more
core  

Effect of symptom clusters on quality of life in patients with head and neck cancer treated with radiotherapy: a cross-sectional study

Scientific Reports
Patients with head and neck cancer (HNC) frequently encounter symptom clusters following radiotherapy, which substantially affect their quality of life.
Rui Zhao, Tingting Ding, Huili Ma, Yanhui Ma, Ailian He, Jiaxun Kang, Yaosong Zhao   +6 more
doaj   +1 more source