Results 161 to 170 of about 24,934 (291)

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, EarlyView.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source

Natural History of Alternaria Sensitisation and Association With Asthma and Rhinitis From Childhood to Adulthood

Allergy, EarlyView.
We aimed to characterise Alternaria sensitisation trajectories from childhood to adulthood; we compared SPT, whole‐extract sIgE and rAlt a 1, and assessed their longitudinal association with asthma and rhinitis in the Isle of Wight birth cohort. Alternaria sensitisation in the Isle of Wight Birth Cohort emerges mainly in late adolescence and, when ...
Mohammad Leily, Hongmei Zhang, Graham Roberts, Pandurangan Vijayanand, Magnus Bores, Eva Södergren, Ramesh J. Kurukulaaratchy, S. Hasan Arshad   +7 more
wiley   +1 more source

Inducing fixation of transgenic alleles in open-pollinated populations. [PDF]

Transgenic Res
Conner AJ, Jacobs JME.
europepmc   +1 more source

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

Indian Seed System Development: Policy and Institutional Options [PDF]

Developments in the Indian seed industry and their impact on access and use of commercial seed by farmers have been examined. Various types of seed systems such as hybrids, self-pollinated crops, vegetatively propagated crops, crops with high seed volume,
Mathur, Prasoon, Pal, Suresh, Singh, Harbir   +2 more
core   +1 more source

Transcriptomic and hormonic analyses reveal the effects of xenia on anthocyanin biosynthesis in blueberry. [PDF]

Food Chem (Oxf)
Yang Q, Xu Z, Wen Z, Lu X, Chen X, Peng S, Liu Y, Gao Z.   +7 more
europepmc   +1 more source

Chironomid‐based summer temperature reconstruction of the Eemian–Weichselian transition at Lichtenberg, northern Germany

Boreas, EarlyView.
Understanding the temperature variability of past interglacial cycles is essential to predict future climates. We present a new summer temperature reconstruction, based on the subfossil chironomid record from a small palaeolake adjacent to the Middle Palaeolithic site of Lichtenberg, northern Germany. The record spans from the Saalian late glacial over
Sonja Rigterink, Bartosz Kotrys, Michael Hein, Xuan Li, Neda Rahimzadeh, Agnieszka Gruszczyńska, Marcel Weiss, Brigitte Urban, David Colin Tanner, Tobias Lauer, Antje Schwalb   +10 more
wiley   +1 more source