Results 101 to 110 of about 569,750 (277)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

To a question of self-presentation in the youth environment [PDF]

open access: yes, 2015
In this article we analysed degree of study of a problem of self-presentation of the psychological and pedagogical theory and practice. Opened concept self-presentation which is understood as process of representation of in the relation socially and ...
Martynova, N.   +1 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Deliberation or Self-presentation?: Young People, Politics and Social Media

open access: yesNordicom Review, 2014
This article presents a study of how politically engaged young people use social media for political purposes. There has been a growing optimism that social media can stimulate political participation and deliberation, especially among young people ...
Storsul Tanja
doaj   +1 more source

Analisis Dramaturgi Pada Self Presentation Presenter Program Oshop Di OChannel [PDF]

open access: yes, 2016
Penelitian ini bertujuan untuk mengetahui peran front stage dan back stage terhadap pembentukan self presentation presenter home shopping di OChannel.
Augustia, M. (Mega)
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Research on Relationship between Personality Traits and Online Behaviour in Adolescents (With VKontakte Social Media as an Example)

open access: yesПсихологическая наука и образование, 2018
The paper presents and discusses outcomes of the first stage of a research project on the role of social media in the life of modern adolescents that was carried out on basis of the MSUPE Centre for Interdisciplinary Research on Modern Childhood in 2015 ...
Rubtsova O.V.,   +2 more
doaj   +1 more source

Psychological conditions of formation of effective self-presentation of future psychologists [PDF]

open access: yes, 2016
У дисертації на основі теоретичного аналізу проблеми запропоновано визначення поняття самопрезентації як поведінкового компоненту структури особистості, у якому реалізується прагнення особистості створити бажаний і водночас адекватний соціальній ситуації
Чигирин, Тетяна Олександрівна
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

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