Results 151 to 160 of about 41,401 (289)

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Active jamming: Self-propelled soft particles at high density

, 2011
We study numerically the phases and dynamics of a dense collection of self-propelled particles with soft repulsive interactions in two dimensions. The model is motivated by recent in vitro experiments on confluent monolayers of migratory epithelial and ...
Silke Henkes, Fily, Yaouen, Yaouen Fily, Henkes, Silke, Marchetti, M. Cristina, M. Cristina Marchetti, Marchetti, M. Christina   +6 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Large-Scale Dynamics of Self-propelled Particles Moving Through Obstacles: Model Derivation and Pattern Formation. [PDF]

Bull Math Biol, 2020
Aceves-Sanchez P, Degond P, Keaveny EE, Manhart A, Merino-Aceituno S, Peurichard D.   +5 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Non‐Reciprocity, Metastability, and Dynamic Reconfiguration in Co‐Assembly of Active and Passive Particles

Advanced Science
Living organisms often exhibit non‐reciprocal interactions where the forces acting on the objects are not equal in magnitude or opposite in direction. The combination of reciprocal and non‐reciprocal interactions between synthetic building blocks remains
Ahmed Al Harraq, Ruchi Patel, Jin Gyun Lee, Ope Owoyele, Jaehun Chun, Bhuvnesh Bharti   +5 more
doaj   +1 more source

Stability of liquid films covered by a carpet of self-propelled surfactant particles

, 2014
We consider a carpet of self-propelled particles at the liquid-gas interface of a liquid film on a solid substrate. The particles exert an excess pressure on the interface and also move along the interface while the swimming direction changes due to ...
Andriy Pototskyy (18923980), Uwe Thiele (1522597), Holger Stark (4694)   +2 more
core   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Enhancing Li‐S Battery Performance Through Low‐Concentration Electrolytes with Organic Se/Te Co‐Additives to Address Solubility and Kinetic Challenges

Advanced Science, EarlyView.
This work presents a low‐concentration electrolyte enabled by hybrid organic Se/Te additives (DPDSe/DPDTe) that restructures solvation, boosts polysulfide dissolution, and provides dual‐site synergistic catalysis, delivering high capacity and stable cycling in Li–S coin and pouch cells, supporting high‐energy, high‐power operation.
Ruihua Li, Haiwei Wu, Hairu Wei, Wenhao Jia, Frederik Bettels, Leon Schenk, Zhihua Lin, Hanbin Liu, Guodong Liu, Zhijian Li, Lin Zhang   +10 more
wiley   +1 more source

Run-and-tumble dynamics of self-propelled particles in confinement

, 2015
Run-and-tumble dynamics is a wide-spread mechanism of swimming bacteria. The accumulation of run-and-tumble microswimmers near impermeable surfaces is studied theoretically and numerically in the low-density limit in two and three spatial dimensions ...
Gerhard Gompper, Elgeti, Jens, Jens Elgeti, Gompper, Gerhard   +3 more
core   +1 more source