Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Experimental tests were conducted with the lizard Liolaemus tenuis (Tropiduridae), to determine the potential sources of pheromones used in its chemical communication, centered in the phenomenon of self-recognition.
Antonieta Labra +3 more
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Self-Recognition in Data Visualization: How People See Themselves in Social Visualizations [PDF]
Self-recognition is an intimate act performed by people. Inspired by Paul Ricoeur, we reflect upon the action of self-recognition, especially when data visualization represents the observer itself.
Cellard, Loup, Rodighiero, Dario
core
Assessing the Multiple Dimensions of the Self-Concept of Young Children: A Focus on Latinos [PDF]
This study was designed to provide psychometric and developmental information for a caregiver report and observational measure of young children\u27s self-concept.
Busch-Rossnagel, Nancy A. +4 more
core +1 more source
Distinguishing personal belief from scientific knowledge for the betterment of killer whale welfare – a commentary [PDF]
We contest publication of Marino et al. regarding captive killer whale (Orcinus orca) welfare because of misrepresentations of available data and the use of citations that do not support assertions. Marino et al. misrepresent stress response concepts and
Abramson, Charles I. +9 more
core
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
“Eyes wide shut”: Paul Ricoeur’s Biblical Hermeneutics and the Course of Recognition in John Milton’s Paradise Lost [PDF]
The author of the paper analyzes John Milton’s great epic narrative through the lenses of Paul Ricoeur’s biblical hermeneutics and his philosophical reflection, in particular the second chapter of the philosopher’s last book, Parcours de la ...
Grzegorzewska, Małgorzata
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source

