Results 41 to 50 of about 165,203 (244)

HJB-based online safety-embedded critic learning for uncertain systems with self-triggered mechanism

CoRR
This paper presents a learning-based optimal control framework for safety-critical systems with parametric uncertainties, addressing both time-triggered and self-triggered controller implementations. First, we develop a robust control barrier function (RCBF) incorporating Lyapunov-based compensation terms to rigorously guarantee safety despite ...
Zhanglin Shangguan, Bo Yang, Qi Li, Wei Xiao, Xingping Guan   +4 more
openaire   +2 more sources

Synchronous MDADT-Based Fuzzy Adaptive Tracking Control for Switched Multiagent Systems via Modified Self-Triggered Mechanism [PDF]

IEEE Transactions on Fuzzy Systems
In this article, a self-triggered fuzzy adaptive switched control strategy is proposed to address the synchronous tracking issue in switched stochastic multiagent systems (MASs) based on mode-dependent average dwell-time (MDADT) method. First, a synchronous slow switching mechanism is considered in switched stochastic MASs and realized through a class ...
Hongjing Liang, Wenzhe Wang, Yingnan Pan, Hak-Keung Lam, Jiayue Sun   +4 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Ordered self-assembly mechanism of a spherical oncoprotein oligomer triggered by zinc removal and stabilized by an intrinsically disordered domain. [PDF]

PLoS ONE, 2012
BACKGROUND: Self-assembly is a common theme in proteins of unrelated sequences or functions. The human papillomavirus E7 oncoprotein is an extended dimer with an intrinsically disordered domain, that can form large spherical oligomers.
Clara Smal, Leonardo G Alonso, Diana E Wetzler, Angeles Heer, Gonzalo de Prat Gay   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Research on Anti-Trojan Malware Mechanism Based on Characteristic Behavior

Dianxin kexue, 2014
Trojans inject systems and launch various attacks, such as eavesdropping secret information, tampering with system configuration etc., which threats to system security seriously.
Weifu Zou, Yiying Zhang, Suxiang Zhang, Chengyue Yang   +3 more
doaj   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Recent Progress in Self-Powered Skin Sensors

Sensors, 2019
Self-powered skin sensors have attracted significant attention in recent years due to their great potential in medical care, robotics, prosthetics, and sports.
Jihong Rao, Zetong Chen, Danna Zhao, Yajiang Yin, Xiaofeng Wang, Fang Yi   +5 more
doaj   +1 more source