Results 51 to 60 of about 9,658,124 (274)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The ‘How’ of Self-Care for Teachers

Providing insights, ideas, strategies and compassion, this book offers a new way of looking at self-care for educators experiencing exhaustion and stress, or who may simply be feeling more tired than they should be.
Lemon, Narelle
core   +1 more source

On self-compassion and self-care in nursing: Selfish or essential for compassionate care?

, 2015
Compassionate care in nursing is increasingly an international concern. While the literature to date has focussed on redressing a compassion and care deficit across the nursing discipline (Crawford et al., 2014, Dewar et al., 2014, Scott, 2014), we ...
Fraser, Jennifer A., Mills, Jason, Wand, Timothy   +2 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Why Self Care is Crucial for Social Workers

, 2023
Practicing self-care is crucial for social workers. The field of social work contains many professions that are rewarding and fulfilling, but they can also be draining for those professionals.
Sloan, Heather
core  

The Interplay Between Self-Determination and Cognitive Bias: Nonlinear Associations Between Myopia Control Knowledge Reserve and Parental Communication Preparedness

Journal of Multidisciplinary Healthcare
Yang Chen,1,* Yijia He,1,* Shenyu Zhao,2,* Jing Zhou,3 Siyuan Wu,4 Xiyang Xia,1 Lingmin Hu,1 Renjie Lu2,51Department of Reproduction, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical ...
Chen Y, He Y, Zhao S, Zhou J, Wu S, Xia X, Hu L, Lu R   +7 more
doaj  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Exploring self-care practices in foster carers: a qualitative study

, 2023
This study aimed to explore how foster carers conceptualize and engage in self-care using interviews with 8 participants. Results suggest that self-care practices are an important component of maintaining the physical and mental health of foster carers ...
Miko, Amy L., Berger, Emily, Krishnamoorthy, Govind   +2 more
core   +1 more source