Results 51 to 60 of about 28,708 (287)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Population genetics of fungal diseases of plants

Parasite, 2008
Although parasitism is one of the most common lifestyles among eukaryotes, population genetics on parasites lag far behind those on free-living organisms.
Giraud T., Enjalbert J., Fournier E., Delmotte F., Dutech C.   +4 more
doaj   +1 more source

Mitonuclear Mismatch is Associated With Increased Male Frequency, Outcrossing, and Male Sperm Size in Experimentally-Evolved C. elegans

Frontiers in Genetics, 2022
We provide a partial test of the mitonuclear sex hypothesis with the first controlled study of how male frequencies and rates of outcrossing evolve in response to mitonuclear mismatch by allowing replicate lineages of C.
Brent W. Bever, Zachary P. Dietz, Jennifer A. Sullins, Ariana M. Montoya, Ulfar Bergthorsson, Vaishali Katju, Suzanne Estes   +6 more
doaj   +1 more source

Pollination ecology and breeding system of two Calceolaria species in Chile [PDF]

, 2014
Indexación: Web of Science; Scielo.Many angiosperms are exclusively dependent on pollinators for its reproduction (Matallana et al.2010; Arroyo et al. 2006).
Cisterna, Jannina, Murúa, Maureen, Rosende, Benito   +2 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Multiple independent origins of auto-pollination in tropical orchids (Bulbophyllum) in light of the hypothesis of selfing as an evolutionary dead end [PDF]

, 2015
Background: The transition from outcrossing to selfing has long been portrayed as an ‘evolutionary dead end because, first, reversals are unlikely and, second, selfing lineages suffer from higher rates of extinction owing to a reduced potential for ...
Alexander Gamisch, Gunter Alexander Fischer, Hans Peter Comes   +2 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Partial Selfing Can Reduce Genetic Loads While Maintaining Diversity During Experimental Evolution

G3: Genes, Genomes, Genetics, 2019
Partial selfing, whereby self- and cross- fertilization occur in populations at intermediate frequencies, is generally thought to be evolutionarily unstable. Yet, it is found in natural populations.
Ivo M. Chelo, Bruno Afonso, Sara Carvalho, Ioannis Theologidis, Christine Goy, Ania Pino-Querido, Stephen R. Proulx, Henrique Teotónio   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

How does selfing affect the dynamics of selfish transposable elements?

Mobile DNA, 2012
Background Many theoretical models predicting the dynamics of transposable elements (TEs) in genomes, populations, and species have already been proposed.
Boutin Thibaud S, Le Rouzic Arnaud, Capy Pierre   +2 more
doaj   +1 more source