Results 181 to 190 of about 47,561 (284)

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Environmental passion and AI literacy shape the impact of green rewards on pro-environmental behaviors. [PDF]

Front Psychol
Xu L, Li Y, Chan TH, Saleem F.
europepmc   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Combination of partial least square structural equation modeling scheme of principal component analysis with importance performance analysis. [PDF]

MethodsX
Otok BW, Alfasanah Z, Aksioma DF.
europepmc   +1 more source

Technostress and Technophobia: Unmasking the Impact of Coerced AI Adoption in Higher Education Institutions

Global Business and Organizational Excellence, EarlyView.
ABSTRACT This article investigates the impact of coerced AI adoption on the psychological well‐being of academic staff within higher education institutions. Data were collected from a sample of 470 faculty members randomly selected from higher education institutions in Pakistan.
Muhammad Imran Qureshi, Mehwish Iftikhar, Samer Ali Al‐shami, Shazia Qayyum   +3 more
wiley   +1 more source

Theoretical Discussion of Applicability and a Practical Example of Using Statistical Second-Generation Techniques to Analyze Causal Relationships in Animal Experiments. [PDF]

Animals (Basel)
Katrin B.
europepmc   +1 more source

Unraveling the Impact of Organizational Ambidexterity: The Role of Integration and Agility in Enhancing Performance amidst Supply Chain Disruptions

Global Business and Organizational Excellence, EarlyView.
ABSTRACT The pandemic and supply chain disruptions are all examples of events that are forcing companies to do business differently. The study was conducted among 405 manufacturing and service companies in Malaysia and analyzed using PLS‐SEM. The role of integration and agility was key to determining how ambidexterity affected the performance of the ...
Muhammad Khalilur Rahman, Arsalan Zahid Piprani, Muhammad Mohiuddin, Sajid Nazir, Adeel Shah   +4 more
wiley   +1 more source

Analisis Perbandingan Penggunaan Perangkat Lunak Analisis Data SEM-PLS dan AMOS Grafis

MEDIA ELEKTRIKA
Terdapat banyak software statistik yang digunakan untuk mengolah atau analisis data yang berguna untuk mengolah data hasil dari penelitian. Jenis software yang populer dewasa ini yaitu SEM PLS dan AMOS Grafis. Tujuan penelitian ini untuk membantu mengetahui software yang tepat untuk data yang akan digunakan pada sebuah penelitian. Metode yang digunakan
openaire   +1 more source

Internationalization, Dynamic Capabilities, and Innovation: Unveiling the Impact on Hotel Chain Performance

Strategic Change, EarlyView.
ABSTRACT The indirect effect of dynamic capabilities on performance has recently emerged as a topic of significant interest and debate in management research. In turbulent environments such as the international hotel industry, where companies constantly innovate to improve their performance, it is important to consider the effect of these dynamic ...
Laura Rienda, Rosario Andreu, Lorena Ruiz‐Fernández   +2 more
wiley   +1 more source