Results 121 to 130 of about 2,717,459 (291)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Steam Reforming of Tar Impurities from Biomass Gasification with Ni-Co/Mg(Al)O Catalysts—Operating Parameter Effects

Fuels
The elimination of tar impurities from biomass gasification by catalytic steam reforming can provide clean syngas for downstream biofuel synthesis (Fischer–Tropsch). The effects of key operating parameters in CH4/tar steam reforming were investigated. Ni-
Ask Lysne, Ida Saxrud, Kristin Ø. Madsen, Edd A. Blekkan   +3 more
doaj   +1 more source

Sem Direitos! Sem Lei! Sem Justiça! Sem Liberdade! Longo Inferno a Todos os Tiranos!

, 2020
The present article discusses the current political situation of Turkey regarding the attacks against the intellectuals and their peace action. “The Academics for Peace” movement, in this respect, is annalyzed to argue the role and the function of the intellectual in society. 1128 professors, in January 2016, had signed an appeal, called “Academics for
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Load Profiles of Charging Stations for Long-Haul Electric Trucks

World Electric Vehicle Journal
Electric trucks play a crucial role in achieving a zero-emission future. As battery electric technology advances, electric trucks are expected to become a cost-effective and sustainable alternative to diesel trucks.
Michele Garau, Ida Buttingsrud Stokke, Odd André Hjelkrem   +2 more
doaj   +1 more source

Sem festim e sem dublê

FronteiraZ. Revista do Programa de Estudos Pós-Graduados em Literatura e Crítica Literária
Este trabalho retoma e expande algumas ideias apresentadas no Trabalho de Conclusão de Curso do autor, intitulado Mundo-sample: a transição neoliberal do Brasil na forma do rap nacional. São analisados três raps do grupo Racionais MC’s, com a intenção de estudar a utilização de referências por parte do grupo: “Capítulo 4, versículo 3”, “Negro Drama” e “
openaire   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Circular economy and Waste-to-Energy: A case study on status and perspectives on CO2 emissions and key incineration properties towards 2035 in the city of Oslo

Waste Management Bulletin
Achieving climate neutrality by 2050 requires significant reductions in greenhouse gas emissions. This study investigates how future changes in municipal solid waste (MSW) generation and composition may affect MSW physical and chemical properties ...
Elisa Magnanelli, Michaël Becidan
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source