Results 1 to 10 of about 56,016 (275)

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III [PDF]

Neuron, 1997
Semaphorins are a large family of secreted and transmembrane proteins, several of which are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified as a receptor for Collapsin-1/Semaphorin III/D (Sema III). We report the identification of a related protein, neuropilin-2, whose mRNA is expressed by developing neurons in ...
Haodong Chen, Alain Chedotal, Zhigang He   +2 more
exaly   +4 more sources

PlexinA1 Autoinhibition by the Plexin Sema Domain [PDF]

Neuron, 2001
Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal. Here, we show that Sema3 signals are transduced equally effectively by PlexinA1 or PlexinA2, but not by PlexinA3.
Takuya Takahashi, Stephen M Strittmatter   +1 more
exaly   +4 more sources

A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition. [PDF]

Obes Rev
ABSTRACT Background In 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
Saghazadeh A, Dolatshahi M, Mohammadi S, Kassani SH, Naghashzadeh M, Ippolito JE, Sirlin CB, Mittendorfer B, Brier MR, Schindler SE, Morris JC, Mou D, Soudah HC, Benzinger TLS, Raji CA.   +14 more
europepmc   +2 more sources

Five-year follow-up of incretin-based therapy in a patient with KCNJ11-related permanent neonatal diabetes: Achieving insulin discontinuation and sulfonylurea reduction. [PDF]

J Diabetes Investig
In a woman with KCNJ11‐related permanent neonatal diabetes mellitus, incretin‐based therapy enabled insulin discontinuation and maintained glycemic control for more than 5 years, with HbA1c between 6.1% and 6.5% on the lowest semaglutide dose, dose‐dependent improvement in insulin secretion, and an approximately 60% reduction in glibenclamide dose ...
Ohkuma T, Aotani R, Sakamoto W, Oshiro A, Ago T.   +4 more
europepmc   +2 more sources

Semaglutide Treatment in Young Adults Living With Type 2 Diabetes: A Post Hoc Analysis From the SUSTAIN and PIONEER Clinical Trials. [PDF]

Diabetes Obes Metab
ABSTRACT Aims Young adults (aged ≤ 40 years) are underrepresented in clinical trials that investigate interventions for those living with Type 2 diabetes (T2D). This study evaluated the efficacy of semaglutide treatment in young adults with T2D by examining the effects on HbA1c and body weight (BW) during the SUSTAIN and PIONEER programmes compared to ...
Zaccardi F, Aroda VR, Arslan EG, Bardtrum L, Goldney J, Ising E, Priyadarshini P, Slater T, Davies MJ.   +8 more
europepmc   +2 more sources

Prevention of Weight Regain After GLP1RA Cessation With Oral TIX100. [PDF]

Diabetes Obes Metab
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5339-5342, June 2026.
Jo S, Chen J, Jing G, Xu G, Li P, Shalev A.   +5 more
europepmc   +2 more sources

Reduced-Frequency GLP1 Therapy Maintains Weight, Body Composition, and Metabolic Syndrome Improvements: A Case Series. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective This study aimed to evaluate whether reduced‐frequency dosing of GLP1 receptor agonists maintains weight loss, body composition, and metabolic syndrome improvements following successful initial treatment with standard weekly therapy. Methods This retrospective case series included 30 adults who achieved weight plateau while on weekly
Wong M, Wu A, Garhe PK, Biermann M.
europepmc   +2 more sources

Fabrication and Preclinical Evaluation of Hyaluronic Acid/Aminoclay Nanocomposite Microneedles for Noninvasive Delivery of Semaglutide in Anti-Obesity Therapy [PDF]

International Journal of Nanomedicine
Chang Rim Woo, Gyu Lin Kim, Hyo-Kyung Han College of Pharmacy, Dongguk University-Seoul, Goyang, KoreaCorrespondence: Hyo-Kyung Han, College of Pharmacy, Dongguk University-Seoul, Dongguk-ro-32, Ilsan-Donggu, Goyang, Korea, Tel +82-31-961-5217, Fax +82 ...
Woo CR, Kim GL, Han HK
doaj   +2 more sources

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Cell & Bioscience, 2022
Background Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted
Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier, Carmela Matrone   +5 more
doaj   +1 more source

SURAT EDARAN MAHKAMAH AGUNG (SEMA) NOMOR 2 TAHUN 2023, AKHIR DARI POLEMIK PERKAWINAN BEDA AGAMA?

Journal Of Scientech Research and Development, 2023
Perkawinan beda agama masih menjadi suatu isu hukum yang hangat dibicarakan oleh pengamat hukum dan masyarakat Indonesia. Hal ini memang tidak dapat dipungkiri mengingat Indonesia merupakan negara yang sangat majemuk dari agama, bahasa hingga ...
B. Kharisma
semanticscholar   +1 more source