Results 1 to 10 of about 12,769 (188)

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III [PDF]

Neuron, 1997
Semaphorins are a large family of secreted and transmembrane proteins, several of which are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified as a receptor for Collapsin-1/Semaphorin III/D (Sema III). We report the identification of a related protein, neuropilin-2, whose mRNA is expressed by developing neurons in ...
Alain Chedotal, Haodong Chen, Marc Tessier-Lavigne   +2 more
exaly   +3 more sources

PlexinA1 Autoinhibition by the Plexin Sema Domain [PDF]

Neuron, 2001
Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal. Here, we show that Sema3 signals are transduced equally effectively by PlexinA1 or PlexinA2, but not by PlexinA3.
Takuya Takahashi, Stephen Strittmatter
exaly   +3 more sources

Fabrication and Preclinical Evaluation of Hyaluronic Acid/Aminoclay Nanocomposite Microneedles for Noninvasive Delivery of Semaglutide in Anti-Obesity Therapy [PDF]

International Journal of Nanomedicine
Chang Rim Woo, Gyu Lin Kim, Hyo-Kyung Han College of Pharmacy, Dongguk University-Seoul, Goyang, KoreaCorrespondence: Hyo-Kyung Han, College of Pharmacy, Dongguk University-Seoul, Dongguk-ro-32, Ilsan-Donggu, Goyang, Korea, Tel +82-31-961-5217, Fax +82 ...
Woo CR, Kim GL, Han HK
doaj   +2 more sources

A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition. [PDF]

Obes Rev
ABSTRACT Background In 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
Saghazadeh A, Dolatshahi M, Mohammadi S, Kassani SH, Naghashzadeh M, Ippolito JE, Sirlin CB, Mittendorfer B, Brier MR, Schindler SE, Morris JC, Mou D, Soudah HC, Benzinger TLS, Raji CA.   +14 more
europepmc   +2 more sources

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Cell & Bioscience, 2022
Background Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted
Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier, Carmela Matrone   +5 more
doaj   +1 more source

High incidence of occupational exposures among healthcare workers in Erbil, Iraq

Journal of Infection in Developing Countries, 2014
Introduction: The current status of percutaneous injury and mucous exposures (PMEs) of hospital workers and factors associated with the injuries have not been studied in Iraq.
Salih Hosoglu, Zana Ahmad, Mohammed Sami Tahseen, Zehra Diyar, Sami Selbes, Ali Colak   +5 more
doaj   +1 more source

Urological assessment results of cases of an undescended testis, pre-diagnosed by pediatricians

Urology Research and Practice, 2019
Objective: In this clinical study, the results of cases, with an undescended testis pre-diagnosed of which initial examinations and inguinal-scrotal ultrasonography examinations were made by pediatricians, was analyzed.
Hamza Yazgan, Mehmet Demirdöven, Esengül Keleş, Arzu Gebeşce, Coşkun Şahin, Mehmet Kalkan   +5 more
doaj   +1 more source

The specifics of the implementation of the concept of “Antichrist” in the novel by D. S. Merezhkovsky “Peter and Alexey” [PDF]

Актуальные проблемы филологии и педагогической лингвистики, 2021
The article is devoted to the study of the concept of “Antichrist” in the language picture of the world by D. S. Merezhkovsky. The relevance of the study is due to the significant role of the writer in the literature of the late 19th-early 20th century ...
Tatiana A. Neverova
doaj   +1 more source

The sema domain

Current Opinion in Structural Biology, 2004
The sema domain was first defined from sequence by Kolodkin and colleagues in the early 1990s, and constitutes the distinctive structural and functional element of semaphorins, their plexin receptors and the receptor tyrosine kinases MET and RON, three protein families with major roles in development, tissue regeneration and cancer. Recently determined
Gherardi, E, Love, CA, Esnouf, RM, Jones, EY   +3 more
openaire   +3 more sources

Women’s health in Northwestern Syria: Findings from Healthy-Syria 2017 study

Avicenna Journal of Medicine, 2019
Objectives: Since the uprising in 2011, there have been limited health-care data from inside Syria regarding women’s health. This study aimed to provide an updated account of women’s health, including pregnancy, perinatal care, childbirth, and other ...
Abdullah Sulieman Terkawi, Basil Bakri, Amena S. Alsadek, Rawaa H. Alsibaee, Esraa M. Alasfar, Amna H. Albakour, Abdulhannan Y. Aljouja, Nour A. Alshaikhwais, Feras A. Fares, Pamela D. Flood, Hussam Jnaid, Amina A. Najib, Diaa A. Saloom, Noran A. Zahra, Khalid A. Altirkawi   +14 more
doaj   +1 more source