Results 191 to 200 of about 4,577,308 (305)

Multivariate age-related variations in quantitative MRI maps: widespread age-related differences revisited. [PDF]

Front Neurosci
Moallemian S, Bastin C, Callaghan MF, Phillips C.   +3 more
europepmc   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Splenic plasticity at the arid limit: dehydration is associated with microanatomical remodelling and B-cell depletion in the dromedary camel (Camelus dromedarius). [PDF]

BMC Zool
Fares MA, Mouane A, Elmounedi N, Mlik R, Chikha M, Ferag A, Messaoudi M, Atoki AV, Faye B.   +8 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Tobacco Use and Motivation to Quit Among Pregnant Women: An Institutional Observational Study from Western Rajasthan. [PDF]

Niger Med J
Garg N, Rajpurohit SS, Bhati BS, Mirza N, Tyagi S, Gupta S, Awasthi A, Suthar N.   +7 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Survival Models for Predictive Maintenance and Remaining Useful Life in Sensor-Enabled Smart Energy Networks: A Review. [PDF]

Sensors (Basel)
Shadi MR, Mirshekali H, Tahavori M, Shaker HR.   +3 more
europepmc   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

From linear models to deep learning: statistical advances in genomic selection for animal breeding. [PDF]

J Anim Sci Biotechnol
Zhang L, Zhang M, Wang X, Chen C, Wang S, Zhao Y, Zhang Y, Wang R, Liu Y.   +8 more
europepmc   +1 more source

Parametric and semi-parametric modelling of vacation expenditures. [PDF]

Melenberg, B., Soest, A.H.O. van
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