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AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

open access: yesAdvanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan   +13 more
wiley   +1 more source

ROC regression as semi-parametric generalized additive models

open access: yesProceedings of the annual meeting of Japanese Society of Computational Statistics, 2015
openaire   +1 more source
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A Semi-parametric Regression Model with Errors in Variables

Scandinavian Journal of Statistics, 2003
Abstract.  In this paper, we consider a partial linear regression model with measurement errors in possibly all the variables. We use a method of moments and deconvolution to construct a new class of parametric estimators together with a non‐parametric kernel estimator.
Hengjian Cui, Lixing Zhu
exaly   +4 more sources

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