Results 111 to 120 of about 259,134 (247)

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Semi-Supervised Classification of Noisy, Gigapixel Histology Images. [PDF]

Proc IEEE Int Symp Bioinformatics Bioeng, 2020
Pulido JV, Guleria S, Ehsan L, Fasullo M, Lippman R, Mutha P, Shah T, Syed S, Brown DE.   +8 more
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Open-World Semi-Supervised Learning for fMRI Analysis to Diagnose Psychiatric Disease

Information
Due to the incomplete nature of cognitive testing data and human subjective biases, accurately diagnosing mental disease using functional magnetic resonance imaging (fMRI) data poses a challenging task.
Chang Hu, Yihong Dong, Shoubo Peng, Yuehan Wu   +3 more
doaj   +1 more source

Semi-Supervised Classification for oil reservoir

, 2018
This paper addresses the general problem of accurate identification of oil reservoirs. Recent improvements in well or borehole logging technology have resulted in an explosive amount of data available for processing. The traditional methods of analysis of the logs characteristics by experts require significant amount of time and money and is no longer ...
Li, Yanan, Guo, Haixiang, Paplinski, Andrew P   +2 more
openaire   +2 more sources

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Improving the Skin‐Conformability of Wearable Continuous Glucose Monitors With Synthetic Hydrogel Electrodes

Advanced Science, EarlyView.
A synthetic hydrogel electrode for skin‐conformable enzymatic biosensing is presented, featuring a stretchable, tape‐shaped continuous glucose monitor for non‐invasive diabetes management. ABSTRACT Synthetic bioelectronics is rapidly advancing, propelled by breakthroughs in synthetic biology and bioelectronics.
Binbin Cui, Shilei Dai, Ivo Pang, Dingyao Liu, Xinran Zhang, Jing Bai, Xinyu Tian, Shiming Zhang   +7 more
wiley   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Improving semi-supervised remote sensing scene classification via Multilevel Feature Fusion and pseudo-labeling

International Journal of Applied Earth Observations and Geoinformation
Remote Sensing Image (RSI) scene classification plays a pivotal role in diverse applications such as land cover mapping, urban planning, and environmental monitoring.
Jiangfan Feng, Hongxin Luo, Zhujun Gu
doaj   +1 more source

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source