Results 121 to 130 of about 230,368 (279)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Zinner syndrome: report of a case and whole exome sequencing

Basic and Clinical Andrology
Background Zinner syndrome is a rare congenital malformation of the male genitourinary system, characterized by a triad: seminal vesicle cyst, unilateral renal agenesis, and ipsilateral ejaculatory duct obstruction.
Jiatai He, Chengcheng Wei, Yu Huang, Feixiang Xu, Miao Wang, Zhaohui Chen   +5 more
doaj   +1 more source

Incidental Zinner Syndrome in Nigeria: A Case Report

European Medical Journal Urology
Zinner syndrome (ZS) is a rare urogenital condition characterised by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction, resulting from malformation during early embryogenesis of the ...
A.O. Takure, B.A. Adewumi, O.E. Fatade, A.O. Adeyinka   +3 more
doaj   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Seminal vesicle cyst with ipsilateral renal agenesis: a case report [PDF]

, 2001
26歳男.上腹部不快感にて近医受診し, 胃内視鏡にて慢性胃炎と診断され, 膀胱背側に嚢胞状の病変と左腎無形性が疑われ当科紹介された.精路との交通を調べる為, 両側精管精嚢造影を施行した.画像上, 左腎無形性, 左尿管精嚢異所開口と診断された.治療方針について苦慮したが, 元来無症状であるため経過観察することとなった.現在5ヵ月経過するも無症状でありTRUS(Transrectal ultrasonography)にても嚢胞の再発は認めていないA 26-year-old man was referred ...
梶田, 洋一郎, 岩城, 秀出洙, 清水, 洋祐, 高尾, 典恭, 山内, 民男   +4 more
core  

Giant seminal vesicle cyst with ipsilateral hypoplastic kidney: Report of a case with review of literature

, 2006
We report a case of a congenital seminal vesicle cyst with ipsilateral hypoplastic kidney in a 51 year-old Indian man presenting with features of bladder outlet obstruction.
DilipKumar Pal, Asim Kumar Bag, Dilip Kumar Pal, AsimKumar Bag, Snehasis Sarkar   +4 more
core   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

[Giant cysts of seminal vesicles].

Acta medica portuguesa, 2014
We report a clinical case of a 60 year-old man, asymptomatic to whom was incidentally found two retrovesical cysts. Physical examination revealed hypogastric, elastic and painless masses; digital rectal examination documented a normal prostate gland. Computerized tomography confirmed the presence of two giant seminal vesicle cysts.
Andrea, Furtado, Fernando, Ferrito, João, Goyri-O'Neill   +2 more
openaire   +1 more source

Bilateral Seminal Vesicle Hypoplasia

, 2022
Background: Seminal vesicles, two coiled sacs located posteriorly to the male bladder and lateral to the ampulla of the ductus deferens, play a vital role in male fertility.
Costello, Kathryn, Cabrero, Daniel, Brown, Kerrie, Butson, Carter, Fisher, Cara L.   +4 more
core