Results 31 to 40 of about 50,818 (280)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The potential role of seminal extracellular vesicles as biomarkers of male fertility and sperm cryotolerance in livestock species

Discover Applied Sciences
Seminal extracellular vesicles are lipid bilayer membrane-bound vesicles that contain the important biomolecules of semen and function in intercellular communication in the reproductive tract.
Sanchi Rana, Farooz Ahmad Lone, João B. F. Souza-Junior, Ghulam Rasool Bhat   +3 more
doaj   +1 more source

Extracellular vesicles, ageing, and therapeutic interventions [PDF]

, 2018
A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals.
Neytchev, Ognian, Panagiotou, Nikolaos, Selman, Colin, Shiels, Paul G.   +3 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Seminal vesicle status and its association with semen parameters in congenital bilateral absence of the vas deferens (CBAVD)

Basic and Clinical Andrology
Background Congenital bilateral absence of the vas deferens (CBAVD) is a rare condition associated with male infertility. CBAVD is often accompanied by other genitourinary anomalies, including abnormalities or agenesis of the seminal vesicles and kidneys.
Iman Shamohammadi, Abdolreza Haghpanah, Ali Eslahi, Mohammad Ali Sadighi Gilani, Ali Adib, Seyyed Sadra Kashfi   +5 more
doaj   +1 more source

A giant retrovesical cystic mass: A rarest of rare with a management dilemma

Urology Case Reports, 2021
A 32-year-old man investigated for subfertility and bladder outlet obstruction. He had a palpable pelvic mass and computerized tomography (CT) pelvis demonstrated that a large cystic mass (15cm) arising from right side seminal vesicle, and another small ...
Meganathan Sivashankar, Neville D Perera, Palehepitiya Gamage Nalin Ruvinda, Thilina Madushan Samarasinghe, N. Navarooban   +4 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Lysyl oxidase promotes seminal vesicle atrophy and fibrosis in type-2 diabetes mellitus through TGF-β1 signaling

Journal of Translational Medicine
Type-2 diabetes mellitus (T2DM) is a complex metabolic disorder that adversely affects various physiological systems, particularly male reproductive health.
Yi Yu, Peng-Fei Liu, Ming-Wei Zhan, Yao-Qi Chen, Yu-Qi Lai, Lei Wang, Jun-Jie Wu, Fan Yao, Xue-Qin Chen, Xue-Jun Shang, Ke-Rong Wu   +10 more
doaj   +1 more source

Peculiarities of seminal vesicles and seminal ducts formation [PDF]

Archives of the Balkan Medical Union, 2018
ntroduction. Recently, decrease in male reproductive function has become particularly relevant. Nowadays, 8 to 29% of married couples are infertile throughout the world.
Khmara T. Volodymyrivna, Ryznychuk M. Aleksandrovna, Kryvchanska M. Ivanivna, Zamorsky I. Ivanovich   +3 more
doaj