Results 121 to 130 of about 1,028,603 (279)

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Advanced Science, EarlyView.
Wall‐associated receptor‐like kinases (WAKLs) play pivotal roles in extracellular–intracellular signal transduction. Upon sensing Verticillium dahliae infestation at the plasma membrane, GbWAKL20 accumulates and transmits signals to the nucleus via endoplasmic reticulum‐mediated Golgi vesicle transport.
Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo   +7 more
wiley   +1 more source

Zariski density of crystalline representations for any p-adic field

, 2013
The aim of this article is to prove Zariski density of crystalline representations in the rigid analytic space associated to the universal deformation ring of a d-dimensional mod p representation of Gal(\bar{K}/K) for any d and for any p-adic field K ...
Nakamura, Kentaro
core  

Interplay Between Time-Temperature-Transformation and the Liquid-Liquid Phase Transition in Water

, 2002
We study the TIP5P water model proposed by Mahoney and Jorgensen, which is closer to real water than previously-proposed classical pairwise additive potentials. We simulate the model in a wide range of deeply supercooled states and find (i) the existence
A. Hallbrucker, D. R. MacFarlane, D. R. Uhlmann, F. H. Stillinger, F. Sciortino, Francesco Sciortino, H. E. A. Huitema, H. Eugene Stanley, I. Borzsák, I. M. Svishchev, I. M. Svishchev, J. M. Sorenson, L. A. Baez, M. Kresin, M. Matsumoto, M. W. Mahoney, M. W. Mahoney, Masako Yamada, O. Mishima, O. Mishima, O. Mishima, O. Mishima, P. G. Debenedetti, P. H. Poole, P. H. Poole, P. H. Poole, R. J. Speedy, R. S. Smith, S. Sastry, Stefano Mossa, W. Götze   +30 more
core   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Reconnection of Colliding Cosmic Strings

, 2005
For vortex strings in the Abelian Higgs model and D-strings in superstring theory, both of which can be regarded as cosmic strings, we give analytical study of reconnection (recombination, inter-commutation) when they collide, by using effective field ...
A. Avgoustidis, A. Hanany, A. Hanany, A. Lawrence, A. Sen, A. Vilenkin, Amihay Hanany, E. Copeland, E.J. Copeland, G. Dvali, G. Dvali, J. Distler, J. Polchinski, J. Polchinski, J. Polchinski, K. Hashimoto, K. Hashimoto, K. Hashimoto, Koji Hashimoto, M. Sakellariadou, M.G. Jackson, N. Barnaby, N. Jones, N. Seiberg, R.A. Matzner, S. Mukhi, S. Nagaoka, T.W.B. Kibble, Y. Okawa   +28 more
core   +1 more source

kNDVI Spatiotemporal Variations and Climate Lag on Qilian Southern Slope: Sen–Mann–Kendall and Hurst Index Analyses for Ecological Insights

Forests
In the context of climate change, the southern slope of the Qilian Mountains stands as a pivotal region for China’s ecological security, holding immense significance for sustaining ecological sustainable development.
Qian Zhang, Guangchao Cao, Meiliang Zhao, Yi Zhang   +3 more
semanticscholar   +1 more source

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

Advanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao, Huaxian Chen, Jiao Li, Yihui Zheng, Liqing Xie, Guozhong Xiao, Zeyan Wang, Fen Yuan, Junhong Chen, Chongbao Sun, Jing Dai, Jinping Zeng, Xinhua Wang, Lei Wu, Hongcheng Lin   +14 more
wiley   +1 more source

A Tangentially Sensitive Tactile Sensor Reveals the Stick‐Slip Mechanism and Enhances Robotic Tactile Sensing

Advanced Science, EarlyView.
An ultralight, multilayer anisotropic tactile sensor—an artificial Pacinian corpuscle—exhibits ultrahigh tangential sensitivity (1022 kPa−1) and spatiotemporal sensing. It discriminates static, sliding, and rolling contacts, detects incipient stick–slip via high‑frequency signatures, and enhances robotic touch (100%/98.18% accuracy for active/passive ...
Jinghui Wang, Xiaoyu Liu, Yujiao Du, Yepu Chen, Jieyi Guo, Linyuan Fan, Min Tang, Xiaofeng Qiao, Yuanjie Zhu, Zhiyang Zhang, Chaojie Dong, Lizhen Wang, Yubo Fan   +12 more
wiley   +1 more source

Analysis of Software Aging in a Web Server [PDF]

A number of recent studies have reported the phenomenon of “software aging”, characterized by progressive performance degradation and/or an increased occurrence rate of hang/crash failures of a software system due to the exhaustion of operating system ...
Grottke, Michael, Liz, Lei, Trivedi, Kishor S., Vaidyanathan, Kalyanaraman   +3 more
core