Results 101 to 110 of about 2,590 (265)
Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA
Advanced Science, EarlyView.We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang +12 more
wiley +1 more source
Water Quality Trends across Select 319 Monitoring Sites in Northwest Arkansas [PDF]
, 2012 Northwest Arkansas contains two 319 priority watersheds that the Arkansas Natural Resources Commission has identified as being impacted by point source and nonpoint source pollution (i.e., phosphorus, nitrogen, and sediment).
Bailey, Bryan W. +2 more
core +2 more sources
Advanced Science, EarlyView.CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang +17 more
wiley +1 more source
Historical trends and future projection of climate at Dhaka city of Bangladesh [PDF]
, 2016 Dhaka, the capital city of Bangladesh is considered as one of the most vulnerable cities of the world to climate change. A study has been carried out to assess the historical changes as well as future changes in the climate of Dhaka city in order to ...
Ahmed Shourav, Md. Sabbir +4 more
core +1 more source
Advanced Science, EarlyView.A multifunctional Bi2Te3@CdS hybrid system is presented for solar‐driven wastewater remediation and indoor disinfection. The catalyst coated on PU foam efficiently harvests visible‐NIR light to generate heat and reactive oxygen species, enabling the rapid mineralization of organic pollutants.
Manish Kumar Sharma +10 more
wiley +1 more source
Intensity of Time and Income Interdependent Multidimensional Poverty: Well-Being and Minimum 2DGAP ; German Evidence [PDF]
Extending the traditional income poverty concept by multidimensional poverty has been of growing interest within the last years. This paper contributes with an analysis of interdepend-ent multidimensional (IMD) poverty intensity of time and income, which
Joachim Merz, Tim Rathjen
core +3 more sources
BarekengThis research aims to analyze the temporal trends of rainfall and temperature in North Sumatra Province, focusing on the Medan and Deli Serdang regions.
Riri Syafitri Lubis +5 more
doaj +1 more source
A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy
Advanced Science, EarlyView.The work developed a closed‐loop hybrid discovery system to rationally design and predict high‐performance Type I PSs for hypoxic tumor therapy. 664 Potential candidates are identified from a dataset through a support vector machine (SVM) classification model, and two candidates are experimentally verified as Type I PSs, which highlighted the potential
Xia Ling +9 more
wiley +1 more source
Spatial-temporal trends and variability of rainfall and temperature in Northern Malawi
Sustainable EnvironmentUnderstanding historical and projected climate variability is critical for developing effective adaptation strategies, particularly in regions highly dependent on rain-fed agriculture.
Jones Mayamiko Patel, Isaac Tchuwa
doaj +1 more source
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced Science, EarlyView.Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source