Results 91 to 100 of about 606,762 (311)
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Advanced Science, EarlyView.Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao +21 more
wiley +1 more source
The Contributions of Professor Amartya Sen in the Field of Human Rights [PDF]
This paper analyses the work of the Nobel Prize winning economist Professor Amartya Sen from the perspective of human rights. It assesses the ways in which Sen's research agenda has deepened and expanded human rights discourse in the disciplines of ...
Polly Vizard
core
ECO-ETHICAL VIEWS OF TAGORE AND AMARTYA SEN
, 2018 Desde que se otorgó el Premio Nobel de Economía a Amartya Sen, se han hecho muchos esfuerzos por destacar el pasado de Sen Shantiniketan y la afinidad de su visión mundial con la de Rabindranath Tagore. Desafortunadamente, es probable que un análisis más
Basu, Ratan Lal, Ratan Lal Basu
core +2 more sources
Advanced Science, EarlyView.In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen +19 more
wiley +1 more source
Nghiên cứu, thiết kế và chế tạo thiết bị phân cỡ hạt sen tươi nguyên vỏ xanh theo kích thước
Tạp chí Khoa học Đại học Cần ThơTrong những năm gần đây, sản phẩm từ hạt sen mang lại hiệu quả kinh tế cao, thúc đẩy nông nghiệp bền vững và góp phần nâng cao đời sống cho người dân vùng Đồng bằng sông Cửu Long.
Nguyễn Văn Tài +4 more
doaj +1 more source
Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis
Advanced Science, EarlyView.In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley +1 more source
, 2012 Recent acts of terrorism and the pro-democracy unrest in the Middle East remind us how important it is to understand the relationship between violence, peace and democracy.
Sen, Amartya
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Advanced Science, EarlyView.Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye +9 more
wiley +1 more source
Documento de consenso de SEMI, semFYC, SEN y SEC sobre ecocardioscopia en España
, 2019 This document summarizes the concept of focused cardiac ultrasound, the basic technical aspects related to this technique, and its diagnostic objectives. It also defines training requisites in focused cardiac ultrasound.
Martínez Sánchez, Patricia +10 more
core +1 more source