Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death [PDF]
Frontiers in Microbiology, 2023 Seneca Valley virus (SVV), a member of the Picornaviridae family, may cause serious water blister diseases in pregnant sows and acute death in newborn piglets, which have resulted in economic losses in pig production.
Xin-yu Zhang +9 more
doaj +5 more sources
Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features. [PDF]
Clin Cancer Res, 2011 Abstract Purpose: Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer. We conducted a first-in-human, first-in-class phase I clinical trial of this agent in patients with cancers with ...
Rudin CM +8 more
europepmc +6 more sources
Genetic evolution and epidemiological analysis of Seneca Valley virus (SVV) in China [PDF]
Virus Research, 2020 Seneca Valley virus (SVV) is a novel Picornaviridae that is closely associated with porcine idiopathic vesicular disease (PIVD). Here, a novel SVV strain (CH-GX-01-2019) was detected and isolated from swine in Guangxi Province, China. The complete genomic sequence of CH-GX-01-2019 exhibited 93.3-98.9 % identify with other SVV isolates at the nucleotide
Jinyong, Zhang +13 more
+5 more sources
Supplementary Figure S1 from Phase I Clinical Study of Seneca Valley Virus (SVV-001),a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features [PDF]
, 2023 <p>Supplementary Figure S1.</p>
Paul L. Hallenbeck +8 more
+4 more sources
, 2023 <div>Abstract<p><b>Purpose:</b> Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer.
Paul L. Hallenbeck +8 more
+4 more sources
In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus [PDF]
Frontiers in Veterinary Science, 2023 IntroductionSurveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed ...
Bo Su +11 more
doaj +3 more sources
Seneca Valley Virus 2C and 3Cpro Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway [PDF]
Frontiers in Microbiology, 2019 Seneca Valley virus (SVV) is the only member of the genus Senecavirus of the Picornaviridae family. SVV can selectively infect and lyse tumor cells with neuroendocrine features and is used as an oncolytic virus for treating small-cell lung cancers ...
Tingting Liu +17 more
doaj +3 more sources
Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth [PDF]
Frontiers in Oncology, 2018 Recent studies reveal that Seneca Valley Virus (SVV) exploits tumor endothelial marker 8 (TEM8) for cellular entry, the same surface receptor pirated by bacterial-derived anthrax toxin.
David J. Evans +5 more
doaj +3 more sources
Rapid detection of Seneca Valley virus based on reverse transcription recombinase polymerase amplification and CRISPR-Cas13a [PDF]
VirulenceThe Seneca Valley virus (SVV) is an emerging novel etiological agent that triggers vesicular stomatitis in pigs. SVV leads to considerable financial detriment to the global swine industry.
Yuhan Wu +13 more
doaj +2 more sources
Molecular Therapy, 2006 A virus was serendipitously isolated, presumably a contaminant of fetal bovine serum, and designated Seneca Valley Virus-001 (SVV-001). SVV-001 has oncolytic activity against adult tumors with neuroendocrine features but is not harmful to normal human cells.
Hales, Laura M. +5 more
openaire +2 more sources