Results 11 to 20 of about 862 (170)

Cryo-EM structure of the Seneca Valley virus A-particle and related structural states [PDF]

Journal of Virology
Picornavirus cell entry requires a series of capsid protein conformational changes leading to genome uncoating. For enteroviruses, receptor binding triggers the transition from a full (F) capsid to an altered (A) particle before releasing its genome and ...
Rosheny Kumaran, Nadishka Jayawardena, Kuan-Lin Chen, Alice-Roza Eruera, James Hodgkinson-Bean, Laura N. Burga, Matthias Wolf, Mihnea Bostina   +7 more
doaj   +2 more sources

Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity [PDF]

Journal of Virology
Seneca Valley virus (SVV) infection gives rise to severe vesicular diseases in pigs, presenting a substantial threat to the global swine industry. The redox imbalance resulting from oxidative stress is an essential pathogenic mechanism during viral ...
Jiangwei Song, Teng Liu, Jingjing Yang, Liwei Zhao, Jiayao Su, Zijian Li, Ruiyi Ma, Xuexia Wen, Peipei Cheng   +8 more
doaj   +2 more sources

Molecular evolution and characterization of novel Seneca Valley virus (SVV) strains in South China

Infection, Genetics and Evolution, 2019
Seneca Valley virus (SVV) is an emerging swine virus associated with porcine vesicular disease. From June to the end of 2017, five SVV strains were isolated from the swine herds in Guangdong, China. Complete genomic sequences of these newly discovered SVV strains were analyzed by genomic and phylogenetic analysis.
Minmin, Wang, Lulu, Chen, Shuonan, Pan, Chunxiao, Mou, Kaichuang, Shi, Zhenhai, Chen   +5 more
openaire   +3 more sources

N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection [PDF]

Viruses, 2021
Seneca Valley virus (SVV) is a picornavirus with potency in selectively infecting and lysing cancerous cells. The cellular receptor for SVV mediating the selective tropism for tumors is anthrax toxin receptor 1 (ANTXR1), a type I transmembrane protein ...
Nadishka Jayawardena, Linde A. Miles, Laura N. Burga, Charles Rudin, Matthias Wolf, John T. Poirier, Mihnea Bostina   +6 more
doaj   +3 more sources

Seneca Valley virus induces mitochondrial apoptosis by activating ER stress or the PERK pathway based on Ca2+ transfer from ER to mitochondria [PDF]

Journal of Virology
Seneca Valley virus (SVV), also known as Senecavirus A, a porcine pathogen that causes vesicular diseases, is prevalent in pig herds worldwide. SVV infection induces endoplasmic reticulum (ER) stress in PK-15 and BHK-21 cells, accompanied by activation ...
Lei Hou, Xiaoyu Yang, Changzhe Liu, Ju Yu, Zhi Wu, Yong Wang, Penghui Zeng, Jinshuo Guo, Yongyan Shi, Jianwei Zhou, Jue Liu   +10 more
doaj   +2 more sources

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication [PDF]

Cellular and Molecular Life Sciences
Seneca Valley virus (SVV) infection leads to severe vesicular diseases in pigs, posing a significant threat to the global swine industry. Ferroptosis, a novel form of non-apoptotic cell death, is characterized by iron-dependent phospholipid peroxidation.
Jiangwei Song, Jingjing Yang, Ruiyi Ma, Zijian Li, Jiayao Su, Shijie Xie, Peipei Cheng   +6 more
doaj   +2 more sources

Seneca Valley Virus Degrades STING via PERK and ATF6-Mediated Reticulophagy [PDF]

Viruses, 2023
Seneca Valley Virus (SVV), a member of the Picornaviridae family, is an emerging porcine virus that can cause vesicular disease in pigs. However, the immune evasion mechanism of SVV remains unclear, as does its interaction with other pathways.
Ling Bai, Rui Zhang, Haixue Zheng, Zhixiong Zhang, Zhidong Zhang, Yanmin Li   +5 more
doaj   +2 more sources

Seneca Valley virus circumvents Gasdermin A-mediated inflammation by targeting the pore-formation domain for cleavage [PDF]

mBio
Members of the gasdermin (GSDM) family are critical for inducing programmable pyroptosis by forming pores on the cell membrane. GSDMB, GSDMC, GSDMD, and GSDME are activated by caspases or granzyme, leading to the release of their autoinhibitory domains ...
Hongyan Yin, Zhenchao Zhao, Ya Yan, Ye Yuan, Weiyu Qu, Haiwei Wang, Cheng Zhu, Pingwei Li, Xin Li   +8 more
doaj   +2 more sources

291. In Vivo Characterization of Seneca Valley Virus (SVV-001), a Novel Oncolytic Picornavirus for Systemic Treatment of Patients with Solid Tumors with Neuroendocrine Features

Molecular Therapy, 2006
Seneca Valley Virus (SVV-001) is a novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of human cancers with neuroendocrine features. In vitro, SVV-001 demonstrates selective oncolytic potency for adult and pediatric human cancer cells which express markers of neuroendocrine differentiation.
Burroughs, Kevin D., Skele, Kristine, Sherk, Christian, Jones, Brian, Vasko, Ann-Jeanette, Hales, Laura, Police, Seshidhar R., Hallenbeck, Paul L.   +7 more
openaire   +2 more sources

Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling [PDF]

Journal of Virology
Seneca Valley virus (SVV) is a newly identified pathogen that poses a notable threat to the global pig industry. SVV has evolved multiple strategies to evade host antiviral innate immune responses.
Zijian Li, Jingjing Yang, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Xuexia Wen, Jue Liu, Jiangwei Song   +8 more
doaj   +2 more sources