Results 21 to 30 of about 862 (170)

A Non-Nucleotide STING Agonist MSA-2 Synergized with Manganese in Enhancing STING Activation to Elicit Potent Anti-RNA Virus Activity in the Cells [PDF]

Viruses, 2023
Both Manganese (Mn2+) and MSA-2 can activate the downstream signal pathway through stimulator of interferon genes (STING) and induce the expression of type I interferon, which is important for hosts to protect against DNA viruses.
Hanrui Lin, Rui Zhang, Hanyi Xiang, Xinqian Lin, Xiongting Huang, Jingsong Chen, Long Zhou, Zhidong Zhang, Yanmin Li   +8 more
doaj   +2 more sources

Copper-mediated MAM regulation of the NF-κB signalling pathway enhances Seneca Valley virus replication in PK-15 cells [PDF]

Veterinary Research
Seneca Valley virus (SVV) is known to cause vesicular disease in swine, presenting new challenges to the pig industry. Recent studies have investigated the relationship between disrupted copper ion homeostasis and viral replication, suggesting that ...
Xiaoli Wu, Song Zhu, Min Li, Zhiwen Xu, Ling Zhu, Junliang Deng, Huidan Deng   +6 more
doaj   +2 more sources

Seneca Valley virus 3C protease targets TRIM32 for cleavage to antagonize its antiviral effects [PDF]

Journal of Virology
The Seneca Valley virus (SVV), a newly emerged virus within the Picornaviridae family, causes porcine idiopathic vesicular disease, imposing substantial economic costs to the global pork industry.
Jingjing Yang, Zijian Li, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Jue Liu, Jiangwei Song   +7 more
doaj   +2 more sources

The Seneca Valley virus 3C protease cleaves DCP1A to attenuate its antiviral effects [PDF]

Veterinary Research
Seneca Valley virus (SVV), a new member of Picornaviridae, causes idiopathic vesicular symptoms in pregnant sows and acute death in neonatal piglets, considerably damaging the swine industry.
Jingjing Yang, Zijian Li, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Xuexia Wen, Jiangwei Song   +7 more
doaj   +2 more sources

Seneca valley virus VP4 protein regulates the transcription of different cytokines in vitro [PDF]

Frontiers in Veterinary Science
To understand the effect of Seneca valley virus (SVV) VP4 protein on innate immune factors, the VP4 gene was cloned into the pEGFP-C1 expression plasmid to construct the pEGFP-C1-VP4 recombinant plasmid. After the recombinant plasmid was transfected into
Chaoliang Leng, Yu Ge, Mengfan Ruan, Wenxiao Zhao, Ximei Yang, Sainan Gao, Hongyue Zhai, Dandan Li, Dan Rao, Jianguo Dong   +9 more
doaj   +2 more sources

Seneca Valley virus infection exploits DNA damage response to facilitate viral replication [PDF]

Journal of Virology
Seneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry.
Jiangwei Song, Zijian Li, Jingjing Yang, Ruiyi Ma, Dan Wang, Rong Quan, Xuexia Wen, Jue Liu   +7 more
doaj   +2 more sources

Leveraging productivity indicators for anomaly detection in swine breeding herds with unsupervised learning [PDF]

Frontiers in Veterinary Science
IntroductionIn swine disease surveillance, obtaining labeled data for supervised learning models can be challenging because many farms lack standardized diagnostic routines and consistent health monitoring systems.
Mafalda Pedro Mil-Homens, Mafalda Pedro Mil-Homens, Chong Wang, Chong Wang, Giovani Trevisan, Fernanda Dórea, Fernanda Dórea, Daniel C. L. Linhares, Derald Holtkamp, Gustavo S. Silva   +9 more
doaj   +2 more sources

Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Recently, the use of oncolytic viruses in cancer therapy has become a realistic therapeutic option. Seneca Valley Virus (SVV) is a newly discovered picornavirus, which has earned a significant reputation as a potent oncolytic agent.
Laura N. Burga, Matthias Wolf, Mihnea Bostina, Nadishka Jayawardena, Richard A. Easingwood, Yoshimasa Takizawa   +5 more
core   +4 more sources

Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon [PDF]

mBio
Nuclear cyclic GMP-AMP synthetase (cGAS) binds to nucleosome with high affinity to prevent its activation by self-DNA. Upon stimulation with double-stranded DNA, cGAS is activated and translocates from the nucleus to the cytoplasm, guided by its N ...
Lei Wu, Ya Yan, Ye Yuan, Zhenchao Zhao, Weiyu Qu, Xiangyu Huang, Haiwei Wang, Pingwei Li, Xin Li   +8 more
doaj   +2 more sources

Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer. [PDF]

Front Mol Biosci
The TEM8 protein coded by the ANTXR1 gene represents an emerging biomarker in solid tumors. In addition to the various roles TEM8 plays in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been ...
Franco LS, Arunachalam S, Chauhan A, Kareff SA, Hallenbeck PL.   +4 more
europepmc   +3 more sources