Results 31 to 40 of about 862 (170)

4. Phase I Study of Seneca Valley Virus (SVV-001), a Replication Competent Oncolytic Virus, in Patients with Neuroendocrine (NE) Cancers [PDF]

Molecular Therapy, 2009
openaire   +2 more sources

Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease. [PDF]

PLoS Pathogens
Inflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18.
Xiangyu Huang, Zhenchao Zhao, Cheng Zhu, Lvye Chai, Ya Yan, Ye Yuan, Lei Wu, Minjie Li, Xiaohan Jiang, Haiwei Wang, Zheng Liu, Pingwei Li, Xin Li   +12 more
doaj   +2 more sources

Isolation and Characterization of Seneca Valley Virus From Pig Transboundary Spread to the Mink Infection. [PDF]

Transbound Emerg Dis
Seneca Valley virus (SVV) infection has recently disseminated across pig farms in Canada, America, and China. The SVV has been identified in humans, rodents, and houseflies. Although cross‐species transmission events may lead to limited subsequent transmission, sustained outbreaks have been observed in new mammalian hosts.
Qin Z, He X, Chen C, Chen S, Nai Z, Wang Y, Wang W, Li G, Wang F, Tian M, He H, Chen H, Liu D, Jiang X.   +13 more
europepmc   +2 more sources

Monitoring swine virus transmission in embryos derived from commercial abattoir oocytes. [PDF]

Front Vet Sci
Pigs are pivotal in agriculture and biomedical research and hold promise for xenotransplantation. Specific-pathogen-free (SPF) herds are essential for commercial swine production and xenotransplantation research facilities.
Pepin B, Rodriguez-Villamil P, Sammel L, Yin J, Dacken B.   +4 more
europepmc   +3 more sources

Phorbol Myristate Acetate Inhibits Senecavirus A Replication by Activating IKBKE-Mediated IFN Pathway and NF-κB Signal. [PDF]

Transbound Emerg Dis
Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease indistinguishable from foot‐and‐mouth disease virus (FMDV). So far, there are no commercial vaccines and effective therapeutic drugs against SVA infection in China. Here, a library of 112 compounds were screened, and we found that phorbol myristate acetate plays an antagonistic ...
Yan J, Gao Y, Guo C, Dong Y, Jiang P, Bai J.   +5 more
europepmc   +2 more sources

CRISPR-Cas13d Exhibits Robust Antiviral Activity Against Seneca Valley Virus

Frontiers in Microbiology, 2022
In recent years, Seneca Valley virus (SVV) as a newly identified pathogen of porcine vesicular disease spread quickly and has posed a potential threat to the swine industry in several countries resulting in economic losses.
Yu-Yuan Zhang, Ming-Xia Sun, Yuexiao Lian, Tong-Yun Wang, Mei-Yu Jia, Chaoliang Leng, Meng Chen, Yuan-Zhe Bai, Fandan Meng, Xue-Hui Cai, Yan-Dong Tang   +10 more
doaj   +1 more source

Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication

Frontiers in Immunology, 2022
Seneca Valley virus (SVV), a non-enveloped positive single-stranded virus can cause vesicular disease in swine. However, the mechanisms by which SVV activates an innate immune response remain unknown.
HuiDan Deng, Song Zhu, Ling Zhu, Ling Zhu, Jing Sun, YuChun Ding, FengQin Li, ZhiJie Jian, Jun Zhao, LiShuang Deng, JunLiang Deng, YouTian Deng, HongRui Guo, XianGang Sun, Si Yuan Lai, HuaQiao Tang, HengMin Cui, Liang Peng Ge, ZhiWen Xu, ZhiWen Xu, ZhiWen Xu   +20 more
doaj   +1 more source

A Fluorescent Immunochromatography Test Strip for the Rapid Identification of SVV and FMDV. [PDF]

Transbound Emerg Dis
Seneca Valley virus (SVV) and foot‐and‐mouth disease virus (FMDV) belong to the Picornaviridae family, which can cause similar symptoms. After infection, pigs will develop fever; loss of appetite; blister lesions on the skin and mucous membrane of the mouth, nose, and hoof; and other similar diseases, and the spread is very fast, causing major economic
Yang L, Li C, Chen X, Li K, Lu Z, Li X, Jin M, Qian P.   +7 more
europepmc   +2 more sources

Pathogenicity of the First Buffalo-origin Senecavirus A in Conventional Piglets and Buffaloes. [PDF]

Transbound Emerg Dis
As the only member of the genus Senecavirus within the family Picornaviridae, Senecavirus A (SVA) has posed an enormous challenge for the pig industry worldwide. In our previous study, a SVA strain was isolated from a buffalo with mouth ulcers. To systematically assess its pathogenicity, this study compared the outcome of piglets and buffaloes ...
Zhou X, Zhai Q, Niu J, Li G, Chen T, Li Y, Kang H, Li C, Gou H, Chu P, Zhang K, Jiang Z, Bian Z, Liao M, Zhai SL.   +14 more
europepmc   +2 more sources

Targeting GBM With an Oncolytic Picornavirus Svv-001 Alone and in Combination With Fractionated Radiation in a Novel Panel of Orthotopic PDX Models [PDF]

, 2023
BACKGROUND: Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells.
Abdallah, Aalaa, Ahmed, Nabil M, Baxter, Patricia A, Brat, Daniel J, Braun, Frank K, Du, Yuchen, Hellenbeck, Paul L, Huang, Frank, Huang, Yulun, Karthick, Sekar, Kogiso, Mari, Li, Xiao-Nan, Patel, Akash J, Qi, Lin, Salsman, Vita S, Su, Jack M, Suarez, Milagros, Teo, Wan-Yee, Xiao, Sophie, Zhang, Huiyuan   +19 more
core   +2 more sources