Results 51 to 60 of about 862 (170)

Expert opinion on the identification, risk assessment, and mitigation of microorganisms and parasites relevant to xenotransplantation products from pigs

Xenotransplantation, Volume 30, Issue 5, September/October 2023., 2023
Abstract Xenotransplantation has the potential to address shortages of organs available for clinical transplantation, but concerns exist regarding potential risks posed by porcine microorganisms and parasites (MP) to the health of human recipients. In this study, a risk‐based framework was developed, and expert opinion was elicited to evaluate porcine ...
Huybert Groenendaal, Solenne Costard, Reid Ballard, Stephen Bienhoff, Diana C. Challen, Brandon J. Dominguez, Douglas R. Kern, Dan Miller, Jeske Noordergraaf, Larisa Rudenko, Henk‐Jan Schuurman, Tom Spizzo, Matthew Sturos, Bill Zollers, Jay A. Fishman   +14 more
wiley   +1 more source

Senecavirus A in Pigs, United States, 2015 [PDF]

, 2016
Citation: Hause, B. M., Myers, O., Duff, J., & Hesse, R. A. (2016). Senecavirus A in Pigs, United States, 2015. Emerging Infectious Diseases, 22(7), 1323-1325.
Duff, J., Hause, Benjamin M., Hesse, Richard A., Myers, O.   +3 more
core   +2 more sources

Oncolytic virotherapy using neural stem cells as a novel treatment option for glioblastoma multiforme

MedComm – Oncology, Volume 2, Issue 1, March 2023., 2023
The oncolytic viruses (OVs) are loaded into neural stem cells (NSCs) which acts as a carrier. The NSCs loaded by OVs are then transferred into the brain where the NSCs release the OVs into the precise tumor locations (GBM tumors). The OVs multiply inside the tumor and carries out oncolysis. The OVs gets liberated to infect more GBM tumors. Abstract The
Tanvir Ahmed
wiley   +1 more source

Distinct roles for the IIId2 sub-domain in pestivirus and picornavirus internal ribosome entry sites. [PDF]

, 2017
Viral internal ribosomes entry site (IRES) elements coordinate the recruitment of the host translation machinery to direct the initiation of viral protein synthesis. Within hepatitis C virus (HCV)-like IRES elements, the sub-domain IIId(1) is crucial for
Allouche, D, Belsham, GJ, Chamond, N, Davids, NA, Fahnøe, U, Hadsbjerg, J, Locker, N, Rajagopalan, N, Rasmussen, TB, Roberts, LO, Sargueil, B, Ulryck, N, Willcocks, MM, Zaini, S   +13 more
core   +4 more sources

Enhanced detection and serotyping of foot‐and‐mouth disease virus serotype O, A, and Asia1 using a novel multiplex real‐time RT‐PCR

Transboundary and Emerging Diseases, Volume 69, Issue 5, Page e2578-e2589, September 2022., 2022
Abstract Rapid and accurate detection and serotyping of foot‐and‐mouth disease (FMD) virus (FMDV) is essential for implementing control policies against emergent FMD outbreaks. Current serotyping assays, such as VP1 reverse transcription‐polymerase chain reaction (RT‐PCR)/sequencing (VP1 RT‐PCR/sequencing) and antigen detection enzyme‐linked ...
Da‐Rae Lim, Soyoon Ryoo, Hyeonjeong Kang, Su Hong Oh, Sang‐Ho Jang, BoKyu Kang, Hye‐Jin Park, Hyeonwoo Hwang, Jae‐Myung Kim, Choi‐Kyu Park, Sang‐Ho Cha   +10 more
wiley   +1 more source

Picornavirus translation strategies

FEBS Open Bio, Volume 12, Issue 6, Page 1125-1141, June 2022., 2022
Upon the entry of the viral RNA into susceptible cells, cis‐ and trans‐regulatory elements coordinately determine picornavirus protein synthesis. Early in the infection, the cap‐dependent translation of host mRNAs is shut down, while viral RNA takes advantage of the IRES element, resulting in efficient synthesis of viral proteins.
Rosario Francisco‐Velilla, Azman Embarc‐Buh, Salvador Abellan, Encarnacion Martinez‐Salas   +3 more
wiley   +1 more source

Seneca Valley Virus 3C^pro Cleaves PABPC1 to Promote Viral Replication

Pathogens, 2020
Seneca Valley Virus (SVV) is an oncolytic virus of the Picornaviridae family, which has emerged in recent years. The impact of SVV on host cell translation remains unknown.
Qiao Xue, Huisheng Liu, Zixiang Zhu, Zhaoning Xue, Xiangtao Liu, Haixue Zheng   +5 more
doaj   +1 more source

Novel Senecavirus A in Swine with Vesicular Disease, United States, July 2015 [PDF]

, 2016
To the Editor: Senecavirus A (SVA; formerly known as Seneca Valley virus [SVV] belongs to the genus Senecavirus, family Picornaviridae (1,2). SVA was first isolated in 2001 as a contaminant of the PER.C6 cell line and designated as SVV-001 (1,3).
Arruda, Bailey, Baum, David, Canning, Paisley, Cooper, Vickie, Gauger, Phillip, Guo, Baoqing, Hoang, Hai, Li, Ganwu, Linhares, Daniel, Linhares, Daniel, Madson, Darin, Main, Rodger, Piñeyro, Pablo, Rademacher, Christopher, Schwartz, Kent, Yoon, Kyoung-Jin, Yuan, Jian, Zheng, Ying   +17 more
core   +3 more sources

Immune cell landscape and immunotherapy of medulloblastoma

Pediatric Investigation, Volume 5, Issue 4, Page 299-309, December 2021., 2021
ABSTRACT Medulloblastoma is the most common primary pediatric malignancy of the central nervous system. Recurrent and refractory patients account for approximately 30% of them. Immune cells are an important component of the brain tumor microenvironment, including tumor‐associated macrophages, T lymphocytes, natural killer cells, dendritic cells ...
Jin Zhang, Tianyou Wang
wiley   +1 more source

Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy. [PDF]

PLoS ONE, 2015
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-
Linde A Miles, W Nathaniel Brennen, Charles M Rudin, John T Poirier   +3 more
doaj   +1 more source