Results 141 to 150 of about 25,541 (267)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Senolytic-loaded asymmetric wound dressing for targeted senescent cell clearance in diabetic wound healing. [PDF]

Mater Today Bio
Zhang M, Wang Y, Dai Y, Hu Y, Fu W, Zhao Y, Ma H, Zhang D, Chen Y, Zhou Y, Du L, Chang J, Liu F, Chen S, Wang F, Xiao D, Li Z.   +16 more
europepmc   +1 more source

Supplementary material to "Does drought advance the onset of autumn leaf senescence in temperate deciduous forest trees?"

, 2020
Bertold Mariën, Inge Dox, Hans J. De Boeck, Patrick Willems, Sebastien Leys, Dimitri Papadimitriou, Matteo Campioli   +6 more
openaire   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF. [PDF]

Cardiovasc Res
Silva ED, Tomé I, Vasques-Nóvoa F, Conceição G, Silva A, Barros AS, Mendes-Ferreira P, Santos-Ribeiro D, Gonçalves A, Angélico-Gonçalves A, Adão R, Caetano C, Sousa D, Miranda-Silva D, Juni RP, Tchkonia T, Kirkland JL, Caramelo F, Gonçalves N, Sampaio-Pinto V, Ribeiro JS, Boon RA, Leite-Moreira A, Pitrez P, Pinto-do-Ó P, Santos SG, Falcão-Pires I, Ferreira L, Nascimento DS.   +28 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Immune cell senescence drives responsiveness to immunotherapy in melanoma. [PDF]

Mol Cancer
Pantelis P, Tremoulis DC, Evangelou K, Bakouros P, Magkouta S, Ntintas OA, Veroutis D, Theocharous G, Kostopoulos IV, Thanos DF, Chatziioannou E, Anastasiou IA, Lagopati N, Valakos D, Skaltsas D, Pop OT, Abdou MT, Gagos S, Kletsas D, Thanos D, Stratigos AJ, Röcken M, Flatz L, Chrousos GP, Vlachakis D, Tsitsilonis OE, Petty R, Karamitros T, Gorgoulis VG.   +28 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Metabolism, senescence, and natural products: new perspectives on wound healing in diabetes. [PDF]

Front Nutr
Wu J, Yang Q, Cheng H, Zheng H, Chen M.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source