Results 71 to 80 of about 25,541 (267)

Polyurethane–polylactide-based material doped with resveratrol decreases senescence and oxidative stress of adipose-derived mesenchymal stromal stem cell (ASCs)

RSC Advances, 2017
The aim of this study was to evaluate the influence of resveratrol (RES)-doped polyurethane (TPU)–polylactide (PLA) biomaterials on the senescence and oxidative stress factor of adipose-derived stem cells (ASCs) for tissue engineering.
K. Kornicka, D. Nawrocka, A. Lis-Bartos, M. Marędziak, K. Marycz   +4 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Supplementary Materials and Figure Legends from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

, 2023
<p>Extended Materials and Methods and Supplementary figures with legends</p>
Joaquín Arribas, Cristina Saura, Javier Cortés, Wim H.A. Dokter, Fred A. Dijcks, Verónica Rodilla, Anna Esteve-Codina, Atanasio Pandiella, Lucía Gandullo-Sánchez, Santiago Escrivá-de-Romaní, Sandra Pérez-Ramos, Marta Escorihuela, Beatriz Morancho, Cristina Bernadó Morales, Enrique Javier Arenas, Marta Lalinde-Gutiérrez, Mercedes Nadal-Serrano, Santiago Duro-Sánchez   +17 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Use of Human Platelet Lysate as a Coating Substance for Adipose-Derived Stem Cell Expansion

Frontiers in Bioscience-Landmark
Background: Large-scale production of mesenchymal stromal cells is essential for sufficient therapeutic doses in regenerative medicine. However, long-term cultivation encounters limited cell growth and cellular aging.
Patcharapa Tragoonlugkana, Narong Chitchongyingcharoen, Chatchai Pruksapong, Shirmeela Hassan, Kamolchanok Ngamkham, Witchayapon Kamprom, Aungkura Supokawej   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cassava wastewater as organic fertilizer in ‘Marandu’ grass pasture

Revista Brasileira de Engenharia Agrícola e Ambiental
This study aimed to evaluate the use of wastewater from the cassava processing as organic fertilizer on pastures of Brachiaria brizantha cv. ‘Marandu’.
Márcio G. S. Bezerra, Gualter G. C. da Silva, Gelson dos S. Difante, João V. Emerenciano Neto, Ermelinda M. M. Oliveira, Luiz E. C. de Oliveira   +5 more
doaj   +1 more source

Cut management of Tithonia diversifolia as a function of regrowth ages: a physiological and morphological approach [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Tithonia diversifolia is exploited in tropical countries as a forage. However, there are no studies on its ecophysiology and relationship with the management of the species. This study aimed to evaluate the post-cut regrowth ages of T.
M.N.S. Souza, L.D. Tuffi Santos, L.M.S. Donato, R.E. Barros, V.D. Machado, L.C. Geraseev   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source