Results 31 to 40 of about 1,556 (255)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Decomposição e liberação de nitrogênio, fósforo e potássio de resíduos da cultura do feijoeiro Decomposition and release of nitrogen, phosphorus and potassium from residues of common bean crop

Revista Brasileira de Ciência do Solo, 2007
Este trabalho teve como objetivo mensurar a velocidade de decomposição e de liberação de nutrientes in situ de resíduos da cultura do feijoeiro (Phaseolus vulgaris L.).
Eduardo Chagas, Adelson Paulo Araújo, Marcelo Grandi Teixeira, José Guilherme Marinho Guerra   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Quality of life among elderly participants in social centers: an integrative review / Qualidade de vida em idosos participantes de centros de convivência: uma revisão integrativa

Revista de Pesquisa Cuidado é Fundamental Online, 2021
Objetivo: analisar as produções científicas acerca da participação dos idosos integrantes de Centros de Convivência para Idosos e a influência destes na qualidade de vida dos participantes.
Anne Carolinne Marie dos Santos Gomes, Kaline De Araújo Medeiros, Ana Karla Maciel Soares, Rossana de Rocci Alves Barbosa Costa, Kay Francis Leal Vieira, Adriana Lira Rufino de Lucena   +5 more
doaj   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Remoción mecánica del material senescente para la recuperación de pasturas

Agronomía Mesoamericana, 2019
Introducción. La acumulación de material senescente en pasturas tropicales es resultado de la alta producción de biomasa y bajo nivel de aprovechamiento en pastoreo. La remoción de senescencia en pasturas permite que el ganado acceda a estratos bajos durante el pastoreo, lo que genera un rebrote con mayor concentración de nutrientes. Objetivo.
Rodolfo WingChing-Jones, Luis A. Villalobos-Villalobos   +1 more
openaire   +6 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Resolvina D1 y navitoclax disminuyen el número de miofibroblastos cardiacos senescentes inducidos por TGF-β1 [PDF]

, 2022
La búsqueda de nuevas terapias relacionadas a las enfermedades cardiovasculares ha cobrado gran relevancia dadas las alarmantes cifras respecto al porcentaje en el padecimiento de estas afecciones a nivel mundial.
Ortega Bustos, Juan Vicente
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source