Results 211 to 220 of about 31,501 (224)

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA.

Developmental Cell
Citation for published version (APA): Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., Hoeijmakers, J. H. J., de Bruin, A., Hara, E., & Campisi, J. (2014).
M. Demaria, Naoko Ohtani, S. Youssef, F. Rodier, Wendy Toussaint, James R. Mitchell, Rémi-Martin Laberge, J. Vijg, H. van Steeg, M. Dollé, J. Hoeijmakers, A. de Bruin, E. Hara, J. Campisi   +13 more
semanticscholar   +1 more source

Lipids and Lipid Metabolism in Cellular Senescence: Emerging Targets for Age-Related Diseases.

Ageing Research Reviews
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP).
Qing Zeng, Yongzhen Gong, Neng Zhu, Ya-ning Shi, Chanjuan Zhang, Li Qin   +5 more
semanticscholar   +1 more source

Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators.

Cell Metabolism
Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses challenges for studying and targeting senescent cells.
Wanyu Tao, Zhengqing Yu, Jing-Dong J. Han   +2 more
semanticscholar   +1 more source

Senescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer

Cancer Discovery
Pancreatic Ductal Adenocarcinoma (PDAC) therapeutic resistance is largely attributed to a unique tumor microenvironment embedded with an abundance of cancer associated fibroblasts (CAFs).
Jad I. Belle, Devashish Sen, John M Baer, Xiuting Liu, Varintra E Lander, Jiayu Ye, B. Sells, B. Knolhoff, A. Faiz, Liang-I Kang, Guhan Qian, Ryan C. Fields, Li Ding, Hyun Kim, Paolo P. Provenzano, S. Stewart, D. DeNardo   +16 more
semanticscholar   +1 more source

Dual-Locked Enzyme-Activatable Bioorthogonal Fluorescence Turn-On Imaging of Senescent Cancer Cells.

Journal of the American Chemical Society
Bioorthogonal pretargeting optical imaging shows the potential for enhanced diagnosis and prognosis. However, the bioorthogonal handles, known for being "always reactive", may engage in reactions at unintended sites with their counterparts, resulting in ...
Xinzhu Wang, S. S. Liew, Jingsheng Huang, Yuxuan Hu, Xin Wei, Kanyi Pu   +5 more
semanticscholar   +1 more source

Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease

Journal of Hepatology
Background: Hepatic stellate cells (HSCs) are the key drivers of fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD), the fastest growing cause of hepatocellular carcinoma worldwide.
Chittampalli N. Yashaswini, Tianyue Qin, Dipankar Bhattacharya, Corina Amor, Scott W. Lowe, A. Lujambio, Shuang Wang, Scott L. Friedman   +7 more
semanticscholar   +1 more source

Efeitos do treinamento de força e de flexibilidade sobre a autonomia de mulheres senescentes

, 2008
R. G. S. Vale, J. Novaes, E. Dantas
semanticscholar   +1 more source