Results 41 to 50 of about 1,556 (255)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Gaceta Médica Espirituana, 2017 Introducción: El abuso hacia los adultos mayores es un problema social y sanitario en aumento debido al incremento de: la expectativa de vida, los avances terapéuticos que prolongan la supervivencia y la pérdida de valores familiares tradicionales ...
Tamara Álvarez Gómez
doaj
Revista Brasileira de Ciência do Solo, 2007 Responses of leaf senescence to P supply could constitute adaptive mechanisms for plant growth under P-limiting conditions. The aim of this study was to evaluate the effects of soil P supply on leaf senescence of common bean (Phaseolus vulgaris L ...
Adelson Paulo Araújo +2 more
doaj +1 more source
Efecto de factores secretados por las células senescentes en la agregación plaquetaria [PDF]
, 2016 63 p.Alteraciones de la agregación plaquetaria son frecuentemente observadas en pacientes con cáncer y están asociadas a un mal pronóstico. Se considera que las células tumorales afectan la activación plaquetaria a través de varios mecanismos (1).
Quintanilla Medina, Ricardo Joel +2 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Enraizamento de estacas e produção de Euryops chrysanthemoides (DC.) B. Nord. em vaso
Ornamental Horticulture, 2016 Os experimentos foram conduzidos no Setor de Floricultura da UFSM no período de agosto de 2013 amaio de 2014, em duas fases experimentais. O primeiro experimento teve o objetivo de verificar o enraizamento de estacas de Euryops chrysanthemoides em ...
Janine Farias Menegaes +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source