Results 61 to 70 of about 31,501 (224)

Macrophage senescence in health and diseases

Acta Pharmaceutica Sinica B
Macrophage senescence, manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype, has long been considered harmful.
Longling Wang, Wenxiang Hong, Hong Zhu, Qiaojun He, Bo Yang, Jiajia Wang, Qinjie Weng   +6 more
semanticscholar   +1 more source

Cellular Senescence: Defining a Path Forward.

Cell, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as
V. Gorgoulis, P. Adams, A. Alimonti, D. Bennett, O. Bischof, C. Bishop, J. Campisi, M. Collado, K. Evangelou, G. Ferbeyre, Jesús Gil, E. Hara, V. Krizhanovsky, D. Jurk, A. Maier, M. Narita, L. Niedernhofer, J. Passos, P. Robbins, C. Schmitt, J. Sedivy, K. Vougas, T. von Zglinicki, Daohong Zhou, M. Serrano, M. Demaria   +25 more
semanticscholar   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Influencia del factor de crecimiento fibroblástico 2 en células madre in vitro

Actualidades Biológicas, 2020
El interés y la necesidad de estudiar las células madre en terapias regenerativas han aumentado en los últimos años debido a su capacidad de proliferación y diferenciación hacia múltiples linajes.
Andrea Catalina Rubio Vargas, Jessica Paola Alcázar Arzuza, Liliana Francis Turner   +2 more
doaj   +1 more source

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Nature Cancer
Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth.
Selim Chaib, J. López-Domínguez, Marta Lalinde-Gutiérrez, N. Prats, I. Marín, Olga Boix, Andrea García-Garijo, Kathleen Meyer, M. I. Muñoz, M. Aguilera, Lidia Mateo, C. Stephan-Otto Attolini, S. Llanos, Sandra Pérez-Ramos, Marta Escorihuela, F. Al-Shahrour, T. Cash, T. Tchkonia, James L. Kirkland, María Abad, Alena Gros, Joaquan Arribas, M. Serrano   +22 more
semanticscholar   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Desenvolvimento de angelônia em vaso, sob doses de adubo de liberação lenta

Ornamental Horticulture, 2018
Angelonia integerrima é uma espécie nativa que possui potencial ornamental podendo ser cultivada em canteiros, floreiras, vasos, ou ainda ser utilizada como complemento em arranjos florais.
Mara Cíntia Winhelmann, Aquélis Armiliato Emer, Marília Tedesco, Priscila Paris, Claudimar Sidnei Fior, Gilmar Schafer   +5 more
doaj   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

Advanced Functional Materials, EarlyView.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough, Roy Chen, Katerina Katsouleas, Jaron Shoemaker, Travis Brady, Tianfang Yu, Jennifer Arthur Ataam, Connor Amelung, Lakshmi Santhanam, Ioannis Karakikes, Sharon Gerecht   +10 more
wiley   +1 more source

Senólisis en el corazón senescente: Una revisión de la literatura actual

Revista Científica CMDLT
La senescencia celular se ha consolidado como un mecanismo biológico fundamental en la patogénesis de las enfermedades cardiovasculares (ECV) asociadas al envejecimiento.
Luis Armando Tirado Fontaines, Daniel Ernesto Foldats   +1 more
doaj   +2 more sources

Decomposição in situ de folhas senescentes de pereira (Pyrus communis L. cv. Rocha) In situ decomposition of pear (Pyrus communis L. cv. Rocha) senescent leaves

Revista de Ciências Agrárias, 2007
Estudou-se a variação da perda de peso e a contribuição das folhas senescentes de pereira (cv. Rocha) para a restituição de azoto (N) ao solo através da técnica dos sacos de decomposição in situ, colocados em Outubro de 2003 à superfície do solo dum ...
C. Neto, C. Carranca, A. de Varennes, J. Clemente, J. Sobreiro   +4 more
doaj