Results 51 to 60 of about 31,501 (224)

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Nature reviews. Molecular cell biology, 2020
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions.
R. Di Micco, V. Krizhanovsky, D. Baker, F. d’Adda di Fagagna   +3 more
semanticscholar   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Senescent glia link mitochondrial dysfunction and lipid accumulation

Nature
Senescence is a cellular state linked to ageing and age-onset disease across many mammalian species1,2. Acutely, senescent cells promote wound healing3,4 and prevent tumour formation5; but they are also pro-inflammatory, thus chronically exacerbate ...
China N. Byrns, Alexandra E. Perlegos, Karl N. Miller, Zhecheng Jin, F. Carranza, Palak Manchandra, Connor H. Beveridge, Caitlin E. Randolph, V. S. Chaluvadi, Shirley L. Zhang, Ananth R. Srinivasan, F. C. Bennett, A. Sehgal, P. Adams, Gaurav Chopra, Nancy M. Bonini   +15 more
semanticscholar   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Nature Aging
It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and that elimination of senescent cells (senolysis) improves age-associated pathologies. Here, we demonstrate that inhibition of sodium–glucose
G. Katsuumi, I. Shimizu, M. Suda, Y. Yoshida, T. Furihata, Y. Joki, C. Hsiao, Liang Jiaqi, S. Fujiki, Manabu Abe, Masataka Sugimoto, Tomoyoshi Soga, Tohru Minamino   +12 more
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cellular senescence: Neither irreversible nor reversible

Journal of Experimental Medicine
Cellular senescence is a stress-inducible terminal cell-cycle arrest program with far-reaching pathophysiologic implications. This Review summarizes the evidence that senescent cells need to actively maintain their arrest machinery and discusses the ...
M. Reimann, Soyoung Lee, Clemens A. Schmitt   +2 more
semanticscholar   +1 more source

Senolytic drugs: from discovery to translation

Journal of Internal Medicine, 2020
Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach.
J. Kirkland, T. Tchkonia
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

¿POR QUÉ ENSEÑAR GERIATRÍA DESDE EL PREGRADO?

Medicentro, 2011
El envejecimiento poblacional de la sociedad cubana es una realidad de gran interés por su tendencia al crecimiento. Cuba será, en los próximos cincuenta años, el país del Tercer Mundo más envejecido; alcanzó un 17,0 % de senescentes en el 20091.
Dr. Ángel Isern Menéndez, Dr. Gilberto García Puentes   +1 more
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