Results 141 to 150 of about 1,556 (255)
Advanced Science, EarlyView.The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang +12 more
wiley +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Estado nutricional del paciente geriátrico hospitalizado.
Gaceta Médica Espirituana, 2012 La edad se acompaña de una serie de circunstancias fisiológicas, económicas y sociales que contribuyen a afectar de una manera adversa el estado nutricional de la población anciana, la hospitalización es una de ellas. El objetivo de la investigación fue
Tamara Álvarez Gómez +5 more
doaj
El envejecimiento es uno de los factores más preponderantes para el desarrollo de enfermedades cardiovasculares (ECV). Uno de los sellos característicos del envejecimiento es la senescencia celular.
Espinoza Pérez, Claudio Andrés
core +1 more source
Advanced Science, EarlyView.Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie +12 more
wiley +1 more source
COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTIMICROBIANA DO ÓLEO ESSENCIAL DAS FOLHAS SENESCENTES DE CÚRCUMA LONGA L. [PDF]
, 2018 Curcuma longa L. (turmeric) leaf is a residual product during root harvesting operations. Traditionally, these leaves, are widely used in cooking, are aromatic and contain essential oil.
FABRI, Eliane Gomes +4 more
core
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Advanced Science, EarlyView.This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang +10 more
wiley +1 more source
, 2017 [ES] La senescencia celular es un estado que se caracteriza por un arresto del ciclo celular permanente y un fenotipo hipersecretor asociado. Originalmente se atribuyó al envejecimiento celular, pero hoy se sabe que puede ser causado por otros.
Blasco Carrasco, Jordi
core
Advanced Science, EarlyView.SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long +12 more
wiley +1 more source