Results 71 to 80 of about 31,501 (224)

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Nature Cell Biology
The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and accumulate in tissues remain to be elucidated.
Julia Majewska, Amit Agrawal, A. Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Sekeresova Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, I. Sopher, J. Perez-Correa, Wolfgang Wagner, Avi Maimon, I. Amit, U. Alon, V. Krizhanovsky   +16 more
semanticscholar   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors

Advanced Materials, EarlyView.
A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li, Di Shen, Ziyang Huang, Suppanat Puangpathumanond, Calvin Thenarianto, Yue Zhao, Jolly Madathiparambil Saju, Rajani Sarojam, Dongmei Zhou, Tedrick Thomas Salim Lew   +9 more
wiley   +1 more source

[Cell senescence, a new target for respiratory viral infections: From influenza virus to SARS-CoV-2]. [PDF]

Bull Acad Natl Med, 2023
Adnot S, Bernard D, Lipskaia L, Trottein F.   +3 more
europepmc   +1 more source

The SASP factor IL‐6 sustains cell‐autonomous senescent cells via a cGAS‐STING‐NFκB intracrine senescent noncanonical pathway

Aging Cell
Senescent cells produce a Senescence‐Associated Secretory Phenotype (SASP) that involves factors with diverse and sometimes contradictory activities. One key SASP factor, interleukin‐6 (IL‐6), has the potential to amplify cellular senescence in the SASP ...
Florencia Herbstein, Melanie Sapochnik, Alejandra Attorresi, C. Pollak, S. Senin, David Gonilski-Pacin, Nicolas Ciancio del Giudice, M. Fiz, Belén Elguero, Mariana Fuertes, Lara Müller, M. Theodoropoulou, Lucas B. Pontel, Eduardo Arzt   +13 more
semanticscholar   +1 more source

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Nature, 2016
Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells
D. Baker, Bennett G. Childs, Matej Durik, M. Wijers, Cynthia J. Sieben, Jian Zhong, Rachel A. Saltness, Karthik B. Jeganathan, Grace C. Versoza, A. Pezeshki, K. Khazaie, Jordan D. Miller, J. V. van Deursen   +12 more
semanticscholar   +1 more source

Electrically Coded Retinomorphic Spectrophotodetector

Advanced Materials, EarlyView.
Self‐powered retinomorphic pyro‐photodetector is demonstrated that avoids machine‐learning post‐processing and covers 365–940 nm. Electrostatic balancing of built‐in potential produces an electrical wavelength code, delivering <3 nm wavelength decoding accuracy with ∼46 µs response.
Mohit Kumar, Hyunmin Dang, Hyungtak Seo
wiley   +1 more source

[Discussion about the presentation: "Cell senescence, a new target for respiratory viral infections: from influenza virus to SARS-CoV-2"]. [PDF]

Bull Acad Natl Med, 2023
Adnot S.
europepmc   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

A proteomic atlas of senescence-associated secretomes for aging biomarker development

bioRxiv, 2019
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of, and promising therapeutic target for, multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a
N. Basisty, Abhijit Kale, Ok-hee Jeon, Chisaka Kuehnemann, Therese Payne, C. Rao, A. Holtz, Samah Shah, Vagisha Sharma, L. Ferrucci, J. Campisi, B. Schilling   +11 more
semanticscholar   +1 more source