Results 61 to 70 of about 1,556 (255)

Microhongos del suelo y asociados a pastos silvestres senescentes en una localidad precordillerana de la 9ª Región [PDF]

, 1993
Mediante métodos de dilución y cámara húmeda, se analizó cualitativa y cuantitativamente la micota presente en el suelo y en su cobertura de pastos senescentes (gramíneas principalmente), en una localidadprecordillerana de pradera en la 9ª región ...
Grixolli, Maria, Piontelli, Eduardo
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Senólisis en el corazón senescente: Una revisión de la literatura actual

Revista Científica CMDLT
La senescencia celular se ha consolidado como un mecanismo biológico fundamental en la patogénesis de las enfermedades cardiovasculares (ECV) asociadas al envejecimiento.
Luis Armando Tirado Fontaines, Daniel Ernesto Foldats   +1 more
doaj   +2 more sources

Decomposição in situ de folhas senescentes de pereira (Pyrus communis L. cv. Rocha) In situ decomposition of pear (Pyrus communis L. cv. Rocha) senescent leaves

Revista de Ciências Agrárias, 2007
Estudou-se a variação da perda de peso e a contribuição das folhas senescentes de pereira (cv. Rocha) para a restituição de azoto (N) ao solo através da técnica dos sacos de decomposição in situ, colocados em Outubro de 2003 à superfície do solo dum ...
C. Neto, C. Carranca, A. de Varennes, J. Clemente, J. Sobreiro   +4 more
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

[Cell senescence, a new target for respiratory viral infections: From influenza virus to SARS-CoV-2]. [PDF]

Bull Acad Natl Med, 2023
Adnot S, Bernard D, Lipskaia L, Trottein F.   +3 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

[Discussion about the presentation: "Cell senescence, a new target for respiratory viral infections: from influenza virus to SARS-CoV-2"]. [PDF]

Bull Acad Natl Med, 2023
Adnot S.
europepmc   +1 more source