Results 71 to 80 of about 249 (181)

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Impacto da aplicação de efluente maturado de fecularia de mandioca em solo e na cultura do sorgo - DOI: 10.4025/actasciagron.v26i4.1801

Acta Scientiarum. Agronomy, 2008
O presente trabalho teve como objetivo avaliar o comportamento da cultura do sorgo submetida a doses de efluente maturado de fecularia de mandioca. Realizou-se o presente trabalho no Centro Técnico de Irrigação da Universidade Estadual de Maringá, Estado
Frederico Fonseca da Silva, Paulo Sérgio Lourenço Freitas, Altair Bertonha, Antonio Saraiva Muniz, Roberto Rezende   +4 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Marcadores de estrés oxidativo en ratas senescentes Oxidative stress markers in aged rats

Revista Cubana de Investigaciones Biomédicas, 2007
Se realizó un estudio sobre los marcadores de daño oxidativo y de defensa antioxidante en órganos de ratas jóvenes, adultas y senescentes; mediante los cuales se evidenció un incremento con el tiempo de la peroxidación lipídica en hígado, corazón, riñón ...
Ela M. Céspedes, Alberto Reyes
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Factores locales y su relación con lesiones bucales en ancianos portadores de prótesis totales

Medisan, 2017
Se realizó un estudio descriptivo y transversal de 96 senescentes portadores de prótesis totales, atendidos enla ClínicaEstomatológica“Lidia Doce Sánchez” de Guantánamo,  desde enero de 2014 hasta abril de 2015, con vistas a determinar la relación entre ...
Marcia Hortensia Corona Carpio, Ana Duharte Escalante, Josefa Navarro Nápoles, Ruth Ramón Jiménez, Lizel Díaz del Mazo   +4 more
doaj  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Influência de bioestimulantes no desenvolvimento vegetativo inicial do milho

Cadernos Cajuína
O milho (Zea mays L.) é uma das principais culturas agrícolas do Brasil, amplamente utilizado na alimentação animal, na indústria e na produção de biocombustíveis.
Izadora Aparecida Turetta Cunha, Gabrielle Oliveira Reis , Milena Oliveira Agrizzi, Luciane da Cunha Codognoto   +3 more
doaj   +1 more source