Results 91 to 100 of about 31,501 (224)

Targeting senescent cells with NKG2D-CAR T cells

Cell Death Discovery
This study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress-induced senescent cells in vitro.
Yushuang Deng, Avadh Kumar, Kan Xie, Kristina Schaaf, Enzo Scifo, Sarah Morsy, Tao Li, Armin Ehninger, Daniele Bano, D. Ehninger   +9 more
semanticscholar   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Efecto cascada en el anciano como consecuencia de la polifarmacia

Medisan, 2017
Se realizó un estudio descriptivo, longitudinal y prospectivo de 52 senescentes con efecto cascada resultante de polimedicación, quienes formaban parte de un total de 305 con enfermedades crónicas no transmisibles, pertenecientes todos al Policlínico ...
Leidys Cala Calviño, Sandra Casas Gross, Liam Kadel Dunán Cruz   +2 more
doaj  

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Impacto da aplicação de efluente maturado de fecularia de mandioca em solo e na cultura do sorgo - DOI: 10.4025/actasciagron.v26i4.1801

Acta Scientiarum. Agronomy, 2008
O presente trabalho teve como objetivo avaliar o comportamento da cultura do sorgo submetida a doses de efluente maturado de fecularia de mandioca. Realizou-se o presente trabalho no Centro Técnico de Irrigação da Universidade Estadual de Maringá, Estado
Frederico Fonseca da Silva, Paulo Sérgio Lourenço Freitas, Altair Bertonha, Antonio Saraiva Muniz, Roberto Rezende   +4 more
doaj   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Marcadores de estrés oxidativo en ratas senescentes Oxidative stress markers in aged rats

Revista Cubana de Investigaciones Biomédicas, 2007
Se realizó un estudio sobre los marcadores de daño oxidativo y de defensa antioxidante en órganos de ratas jóvenes, adultas y senescentes; mediante los cuales se evidenció un incremento con el tiempo de la peroxidación lipídica en hígado, corazón, riñón ...
Ela M. Céspedes, Alberto Reyes
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Actividad antialimentaria e insecticida de un extracto de hojas senescentes de Melia azedarach (Meliaceae) Antifeedant and insecticide activity of an extract from senescent leaves of Melia azedarach (Meliaceae)

Revista de la Sociedad Entomológica Argentina, 2003
Continuando con la búsqueda de nuevos insecticidas naturales obtenidos de plantas, se estudió la actividad de un extracto de hojas senescentes (amarillas) de Melia azedarach L. (Meliaceae).
Graciela Valladares, Lucas Garbin, María T. Defagó, Cecilia Carpinella, Sara Palacios   +4 more
doaj  

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source