Results 51 to 60 of about 288,084 (264)
Advanced Science, EarlyView.Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang +7 more
wiley +1 more source
Advanced Science, EarlyView.This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang +17 more
wiley +1 more source
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions
Advanced Science, EarlyView.This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies +14 more
wiley +1 more source
Advanced Science, EarlyView.We developed a real‐time, label‐free, high‐throughput cell‐on‐a‐chip system based on a metasurface plasmon resonance colorimetric sensor (MetaSPRCS) to evaluate intestinal barrier function. This platform enables continuous monitoring of cell adhesion, proliferation, and barrier layer formation, disruption, and repair.
Youqian Chen +14 more
wiley +1 more source
Ancaman, Faktor Protektif, dan Resiliensi Remaja di Kota Bogor
Jurnal Ilmu Keluarga dan Konsumen, 2019 Adolescents are vulnerable to risky behavior so adolescents must have resilience or ability to face challenging, changing, and difficult situations that are impossible to avoid in human life. This study aimed to analyze factors that influence adolescents’
Siti Maesaroh +2 more
doaj +1 more source
Advanced Science, EarlyView.Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan +17 more
wiley +1 more source
Asian Journal of Assessment in Teaching and Learning, 2018 The purpose of this research study was to determine the teaching techniques and strategies use by the dressmaking teachers perceive by the dressmaking students of Reina Mercedes Vocational and Industrial School. This research aims to answer the following:
Mary Rose Dancel Castro +2 more
doaj +1 more source
AGING MEDICINE, EarlyView.Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang +3 more
wiley +1 more source
Senior High School Students' Entrepreneurial Inclination
Journal of Entrepreneurship and Business, 2021 The study investigates the entrepreneurial inclination of senior high school students in Pampanga, Philippines. Specifically, the undertaking examines the significant differences in respondents? inclination towards entrepreneurship when grouped based on school affiliation, age, sex, plan to pursue a college degree, and family business background.
openaire +1 more source