Results 231 to 240 of about 321,342 (308)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

SRP-Net: sensitive risk propagation network with asymmetric cross-attention for educational data. [PDF]

Sci Rep
Hu J, Guo X, Hu T, Shen J, Zheng M.
europepmc   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Optimized CAP cut-offs for metabolic dysfunction associated steatotic liver disease in patients living with obesity: a large biopsy-based prospective study. [PDF]

Sci Rep
Soliman R, Elbasiony M, Helmy A, Mikhail N, Ezzat H, Gad AM, Halim EA, Zalata K, Masoud R, Hassan A, Farahat A, El Emam M, Shiha G.   +12 more
europepmc   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

Meta-Analysis: Enhanced Liver Fibrosis (ELF) Test for Identifying Significant Fibrosis, Advanced Fibrosis, and Cirrhosis in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Aliment Pharmacol Ther
Gee MFW, Chalfin DB, De Vol EB, Levy HR, Boltyenkov AT, Casale MG, Sanyal AJ.   +6 more
europepmc   +1 more source

Drift Reduction in 2D PtSe2 Piezoresistive Pressure Sensors Through an On‐Chip Wheatstone Bridge

Advanced Electronic Materials, EarlyView.
Drift is a major source of error affecting the accuracy and repeatability of sensors. A Wheatstone bridge (WSB) enables high sensitivity, accuracy, and the elimination of common‐mode drift. We apply the WSB concept to highly sensitive piezoresistive pressure sensors made with two‐dimensional layered platinum diselenide transducers.
Ragini Gupta, Sebastian Lukas, Nico Rademacher, Michael Gross, Nikolas Dominik, Georg S. Duesberg, Max C. Lemme   +6 more
wiley   +1 more source

Correction: Physiological and behavioural responses of wandering albatross chicks (Diomedea exulans) to novel and non-novel predators. [PDF]

J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Cotton A, Barbraud C, Leclaire S, Delord K, Bodin A, Stier A, Ribout C, Parenteau C, Ferdy JB, Bourgoin C, White J, Angelier F, Blanchard P.   +12 more
europepmc   +1 more source

Correction to: “Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis”

Advanced Science, EarlyView.
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source