Results 81 to 90 of about 289,299 (297)

Le flou des Lumières [PDF]

open access: yesSvět Literatury
One might think that the whole Enlightenment enterprise, continuing the movement begun by Descartes, was aimed at producing clear, distinct knowledge, and rejecting shadows, blurring and, in general, anything that falls on the side of the indefinite, the
Colas Duflo
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The Relationship of Type A Personality, Sensation Seeking Trait with General Health among Firefighters in Tehran City

open access: yesJournal of Client-centered Nursing Care, 2015
Background: One of the conditions affecting mental health is working condition which should be considered more. Work-related stress can impair mental health.
Anahita Khodabakhshi Koolaee   +1 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Des monts et des mondes: ce que le corps des marcheurs solitaires fait à la sociologie

open access: yesM@GM@, 2009
En faisant de l’expérience de la marche solitaire un détour permettant d’éclairer les racines sensibles et la dimension corporelle du vivre-ensemble que la culture moderne refoule et rend inopérantes, l’enjeu de notre propos est le suivant: caractériser ...
Jérémy Damian
doaj  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

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