Results 81 to 90 of about 466,447 (335)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

REPRESENTATIONS OF REALITY IN THE DEMARCATION ZONE BETWEEN REASON AND SENSATION IN ENGLISH AND BULGARIAN LANGUAGE ADVERTISING DISCOURSE [PDF]

open access: yesStudies in Linguistics, Culture, and FLT, 2018
The paper deals with different representations of reality in the demarcation zone between reason and sensation in English and Bulgarian language advertising discourse.
Rumyana Todorova
doaj   +1 more source

Noncontact Thermal and Vibrotactile Display Using Focused Airborne Ultrasound [PDF]

open access: yesarXiv, 2020
In a typical mid-air haptics system, focused airborne ultrasound provides vibrotactile sensations to localized areas on a bare skin. Herein, a method for displaying thermal sensations to hands where mesh fabric gloves are worn is proposed. The gloves employed in this study are commercially available mesh fabric gloves with sound absorption ...
arxiv  

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Effect of a Structured Sensory Stimulation Program on the Sensory Function of Patients with Stroke-induced Disorder of Consciousness [PDF]

open access: yesJournal of Evidence-Based Care, 2017
Background: About 50% of stroke patients suffer from the disorder of consciousness with such adverse effects as sensory deprivation. The provision of a care program consisting of simple and safe stimulations can prevent sensory deprivation and improve ...
Khadijeh Sargolzaei   +4 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Presenting Static Friction Sensation at Stick-slip Transition using Pseudo-haptic Effect [PDF]

open access: yesarXiv, 2019
Previous studies have aimed at creating a simple hardware implementation of surface friction display. In this study, we propose a new method for presenting static frictional sensation using the pseudo-haptic effect as a first attempt, which is the simplest implementation of presenting static friction sensation.
arxiv  

Haptic Sensation-Based Scanning Probe Microscopy: Exploring Perceived Forces for Optimal Intuition-Driven Control [PDF]

open access: yesarXiv, 2022
We demonstrate a cryogenic scanned probe microscope (SPM) that has been modified to be controlled with a haptic device, such that the operator can `feel' the surface of a sample under investigation. This system allows for direct tactile sensation of the atoms in and on top of a crystal, and we simulate, by using different SPM modalities, a sensation ...
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

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