Results 71 to 80 of about 207,441 (327)

Cognitive Motivations and Sensation Seeking as Long-Term Predictors of Drinking Problems [PDF]

open access: yes, 1993
The development of comprehensive theories regarding the determinants ofvulnerability toward drinking problems depends in part on longitudinal evidencelinking psychosocial precursors to clinically-relevant problem consequences.
Bentler, Peter M.   +2 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Sensation Seeking Pada Perempuan Pendaki Gunung [PDF]

open access: yes, 2018
Various accidental phenomena of female climber often occur as extreme acts as a form of search gratification of sensation. This study aims to understand the search sensation in women mountaineers.
, Wisnu Sri Hertinjung, S.Psi, M.Psi, Psi   +1 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

PENGARUH MOTIVASI, CITRA DESTINASI, DAN SENSATION-SEEKING TERHADAP NIAT MENGUNJUNGI PULAU BELITUNG [PDF]

open access: yes, 2017
MARGARETHA ESTIANA, The Effect of Motivation, Destination Image, and Sensation-seeking Towards The Intention to Visit Belitung Island. Thesis, Jakarta, Study Program of Commerce Education, Faculty of Economics, State University of Jakarta.
Estiana, Margaretha
core   +1 more source

Sexual Sensation Seeking: A Validated Scale for Spanish Gay, Lesbian and Bisexual People [PDF]

open access: yes, 2018
This is a pre-print of an article published in AIDS and Behavior. The final authenticated version is available online at: https://doi.org/10.1007/s10461-018-2182-6Sexual Sensation Seeking has been identified as a main predictor of unsafe sex that ...
Ballester-Arnal, Rafael   +4 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Online gaming addiction: the role of sensation seeking, self-control, neuroticism, aggression, state anxiety and trait anxiety [PDF]

open access: yes, 2010
Research into online gaming has steadily increased over the last decade, although relatively little research has examined the relationship between online gaming addiction and personality factors.
Biao-Bin V   +6 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Sensation seeking and psychoactive substance consumption: differences between a consumer and a non-consumer simple

open access: yesMedUNAB, 2019
Introduction. Internationally, there have been several studies carried out in order to demonstrate the relationship between a high level of Sensation Seeking and illegal drug abuse. However, few studies in Colombia replicate those results.
González-Gallo, Iván   +1 more
doaj   +1 more source

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