Results 121 to 130 of about 1,797,253 (294)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

What makes us conscious of our own agency? And why the conscious versus unconscious representation distinction matters

Frontiers in Human Neuroscience, 2014
Existing accounts of the sense of agency tend to focus on the proximal causal history of the feeling. That is, they explain the sense of agency by describing the cognitive mechanism that causes the sense of agency to be elicited.
Glenn eCarruthers
doaj   +1 more source

Missiological Education by Extension: A Case Study of the Course, “Foundations of the World Christian Movement” [PDF]

, 2010
This article is a case study of a simple online course created jointly by a mission agency and small university. It demonstrates how open source course management technology has been used to create a true sense of community among students from a variety ...
Smith, Rick, Snodderly, Mary E.
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Dopamine and sense of agency: Determinants in personality and substance use.

PLoS ONE, 2019
Sense of agency refers to the feeling of control over one's own actions. The strength of this sense varies inter-individually. This means that people differ in their perception concerning the intensity of their intentions and actions.
Anna Render, Anna Render, Petra Jansen
doaj   +1 more source

The Relegation of Bilbo: The Narrative Diminishment of Mr. Bilbo Baggins Across J.R.R. Tolkien’s Legendarium [PDF]

, 2017
Despite the relative clarity with which Bilbo was conceptualized and written, Bilbo’s role within the Legendarium at large – and even his role within his own text, The Hobbit – has proved definitively lacking.
Stein, Katherine
core   +1 more source

The Freedom(s) within Collective Agency: Tuomela and Sartre [PDF]

, 2020
In this paper, the goal is to investigate the nature of freedom enjoyed by participants in collective agency. Specifically, we aim to address the fol- lowing questions: in what respects are participants in collective agency able to exercise freedom in ...
Vassilicos, Basil
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Evaluating sense of embodiment in virtual reality with EEG: A scoping review

Computers in Human Behavior Reports
In Virtual Reality (VR) experiences, embodiment refers to owning and controlling a virtual body. It combines Sense of Body Ownership, Sense of Agency, and Sense of Self Location, making the users feel that the virtual body is their own.
Sara Arlati, Marta Mondellini, Giovanna Rizzo, Alfonso Mastropietro   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source