Results 251 to 260 of about 1,797,253 (294)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Sense of agency in the human brain

Nature Reviews Neuroscience, 2017
In adult life, people normally know what they are doing. This experience of controlling one's own actions and, through them, the course of events in the outside world is called 'sense of agency'. It forms a central feature of human experience; however, the brain mechanisms that produce the sense of agency have only recently begun to be investigated ...
Patrick Haggard
exaly   +4 more sources

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Vicarious ostracism reduces observers’ sense of agency

Consciousness and Cognition, 2023
Previous findings revealed that social ostracism reduces people's implicit sense of agency. Based on theoretical claims that observed behavior of others may be cognitively represented similarly to one's own behavior, we conducted two experiments to test whether people's own sense of agency can also be impaired by observed social exclusion of others. In
Yingbing Sun, Bernhard Hommel, Ke Ma
openaire   +2 more sources

The Sense of Supernatural Agency

Journal of Cognition and Culture, 2021
Abstract The sense of supernatural agency constitutes a defining characteristic of the religious sphere of life. But what accounts for the continued cross-cultural recurrence of this psychological phenomenon over the course of human history? This paper reviews evidence indicating that the source of panhuman or universal cognitive patterns of thought ...
openaire   +1 more source

Experience of agency and sense of responsibility

Consciousness and Cognition, 2011
The experience of agency refers to the feeling that we control our own actions, and through them the outside world. In many contexts, sense of agency has strong implications for moral responsibility. For example, a sense of agency may allow people to choose between right and wrong actions, either immediately, or on subsequent occasions through learning
Moretto, Giovanna, Walsh, Eamonn, Haggard, Patrick   +2 more
openaire   +3 more sources

The sense of agency

2017
It has been recognized that the sensorimotor approach needs to be extended to account for not only the pragmatic aspects of perception but also the subjective phenomenology that characterizes experiences of the world and the self. In this chapter, the notion is proposed that sensorimotor agency can serve as the basis for a non-representational, world ...
Ezequiel A. Di Paolo, Thomas Buhrmann, Xabier E. Barandiaran   +2 more
openaire   +1 more source

A sense of agency

Studies in Language, 2018
AbstractRoper Kriol exhibits variation in the shape of the first-person singular pronoun in subject position. This paper provides an account of the numerous syntactic, semantic and pragmatic factors that appear to influence the selection of eitheraiormibased predominantly on a study of a corpus of the written language. It is claimed that the synchronic
openaire   +1 more source

Outcome processing and the sense of agency

Consciousness and Cognition, 2020
People can distinguish outcomes they cause from those they do not; that is, they are quite able to sense self-agency in outcomes. A well-received idea is that the sense of agency is produced by a comparison between a predicted outcome and the actual outcome that occurs.
Nicholas, Hon, Jin-Lin, Sim
openaire   +2 more sources