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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
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Metabolic sensing and control in mitochondria
Molecular Cell, 2023Mitochondria are membrane-enclosed organelles with endosymbiotic origins, harboring independent genomes and a unique biochemical reaction network. To perform their critical functions, mitochondria must maintain a distinct biochemical environment and coordinate with the cytosolic metabolic networks of the host cell.
Yuyang Liu, Kıvanç Birsoy
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Controlled sensing for sequential estimation
2013 IEEE Global Conference on Signal and Information Processing, 2013In this paper, we consider the problem of sequential estimation of a random parameter under a controlled setting. Unlike traditional estimation problems, the collected observations depend on the used actions, which control the quality of the sensing process.
Atia, George, Aeron, Shuchin
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Controlled sensing for hypothesis testing
2012 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2012In this paper, the problem of multiple hypothesis testing with observation control is considered. The structure of the optimal controller under various asymptotic regimes is studied. First, a setup with a fixed sample size is considered. In this setup, the asymptotic quantity of interest is the optimal exponent for the maximal error probability.
Sirin Nitinawarat +2 more
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